Ayyappan K. Rajasekaran, Ph.D.
Director, Nemours Center for Childhood Cancer Research, A.I. duPont Hospital for Children
Rajasekaran
Phone: (302) 651-6593
Fax: (302) 651-6897
Email: araj@medsci.udel.edu
Address:
Nemours Center for Childhood Cancer Research
Rockland Center I-242
Department of Biomedical Research
A.I. duPont Hospital for Children
1600 Rockland Road
Wilmington, DE 19803
Education
- B.S., M.S. - University of Madras (India)
- Ph.D. - Indian Institute of Science (India)
Nemours Education and Research Program
An Alliance to Foster Biomedical Research Between the Department of Biological Sciences at the University of Delaware and Nemours Biomedical Research at the Alfred I. duPont Hospital for Children/Nemours Children's Clinic
Research Interests
- Role of Na,K-ATPase in epithelial cell development and cancer
- Biogenesis of tight junctions and desmosomes
- Role of Na,K-ATPase in cell signaling
- Biology of prostate specific membrane antigen
Current Projects
- Understanding the role or Na,K-ATPase in epithelial morphogenesis and cancer
- Investigations on the intracellular trafficking and the function of prostate specific membrane antigen
Research Group
- Sonali Barwe, Ph.D. - Assistant Research Scientist. Studying the mechanism of cell-cell adhesion function of Na,K-ATPase.
- Thu Huynh - Graduate Student. Studying the role and regulation of Na,K-ATPase Beta-subunit in Cancer Cells.
Selected Publications
- Barwe SP, Maul RS, Christiansen JJ, et al. Preferential association of prostate cancer cells expressing prostate specific membrane antigen to bone marrow matrix. Int J Oncol. 2007;30(4):899–904.
- Cui X, Zhang L, Luo J, et al. Unphosphorylated STAT6 contributes to constitutive cyclooxygenase-2 expression in human non-small cell lung cancer. Oncogene. 2007;26(29):4253–4260.
- Goodman OBJ, Barwe SP, Ritter B, et al. Interaction of prostate specific membrane antigen with clathrin and the adaptor protein complex-2. Int J Oncol. 2007;31(5):1199–1203.
- Olson WC, Heston WDW, Rajasekaran AK. Clinical trials of cancer therapies targeting prostate-specific membrane antigen. Rev Recent Clin Trials. 2007;2(3):182–190.
- Rajasekaran SA, Rajasekaran AK. Epithelial to Mesenchymal Transition. In: Cancer Encyclopedia.; 2007:in press.
- Rajasekaran SA, Barwe SP, Gopal J, Ryazantsev S, Schneeberger EE, Rajasekaran AK. Na-K-ATPase regulates tight junction permeability through occludin phosphorylation in pancreatic epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2007;292(1):G124–33.
- Anilkumar G, Barwe SP, Christiansen JJ, Rajasekaran SA, Kohn DB, Rajasekaran AK. Association of prostate-specific membrane antigen with caveolin-1 and its caveolae-dependent internalization in microvascular endothelial cells: implications for targeting to tumor vasculature. Microvasc Res. 2006;72(1-2):54–61.
- Barwe SP, Rajasekaran SA, Rajasekaran AK. Identification of protein kinase C as an intermediate in Na,K-ATPase beta-subunit mediated lamellipodia formation and suppression of cell motility in carcinoma cells. Cell Mol Biol (Noisy-le-Grand). 2006;52(8):41–47.
- Christiansen JJ, Rajasekaran AK. Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis. Cancer Res. 2006;66(17):8319–8326.
- Christiansen JJ, Weimbs T, Bander N, Rajasekaran AK. Differing effects of microtubule depolymerizing and stabilizing chemotherapeutic agents on t-SNARE-mediated apical targeting of prostate-specific membrane antigen. Mol Cancer Ther. 2006;5(10):2468–2473.
- Liu W, Konduri SD, Bansal S, et al. Estrogen receptor-alpha binds p53 tumor suppressor protein directly and represses its function. J Biol Chem. 2006;281(15):9837–9840.
