George R. Dodge, Ph.D.
Adjunct Associate Professor
Visiting Associate Professor of Orthopaedic Surgery, University of Pennsylvania
Research Associate Professor of Pediatrics, Thomas Jefferson University
Dodge
Phone: (215) 573-1514
Email: gdodge@mail.med.upenn.edu
Address:
McKay Orthopaedic Research Laboratory
Department of Orthopaedic Surgery
University of Pennsylvania
424G Stemmler Hall
36th Street and Hamilton Walk
Philadelphia, PA 19104-6081
Education
- B.S. - State University of New York at Brockport
- Ph.D. - McGill University (Canada)
- Postdoctoral - Thomas Jefferson University
Research Interests
- Cartilage extracellular matrix
- Chondrocyte cell biology
- Regulation of matrix gene expression in Arthritis
Current Projects
- Characterization of alternaive-spliced forms of Perlecan(a large heparan sulfate proteoglycan)and its regulation in vivo
- Mechanism of glucosamine on chondrocyte function and potential as a achondroprptective agent
- Novel approaches of imaging and detection of carialge proteoglycans by MRI
- The role the microenvirnment has in chondrocyte and osteocyte function and cell death
- Leptin's role in bone growth
- Platelet Growth factors and role in angiogenesis and bone healing
- Electrical stimulation of bone and cartilage a model of epiphysiodesis
Selected Publications
- Novotny JE, Turka CM, Jeong C, et al. Biomechanical and magnetic resonance characteristics of a cartilage-like equivalent generated in a suspension culture. Tissue Eng. 2006;12(10):2755–2764.
- Wheaton AJ, Dodge GR, Borthakur A, Kneeland JB, Schumacher HR, Reddy R. Detection of changes in articular cartilage proteoglycan by T(1rho) magnetic resonance imaging. J Orthop Res. 2005;23(1):102–108.
- Wheaton AJ, Dodge GR, Elliott DM, Nicoll SB, Reddy R. Quantification of cartilage biomechanical and biochemical properties via T1rho magnetic resonance imaging. Magn Reson Med. 2005;54(5):1087–1093.
- Wheaton AJ, Borthakur A, Dodge GR, Kneeland JB, Schumacher HR, Reddy R. Sodium magnetic resonance imaging of proteoglycan depletion in an in vivo model of osteoarthritis. Acad Radiol. 2004;11(1):21–28.
- Wheaton AJ, Casey FL, Gougoutas AJ, et al. Correlation of T1rho with fixed charge density in cartilage. J Magn Reson Imaging. 2004;20(3):519–525.
- Dodge GR, Jimenez SA. Glucosamine sulfate modulates the levels of aggrecan and matrix metalloproteinase-3 synthesized by cultured human osteoarthritis articular chondrocytes. Osteoarthritis Cartilage. 2003;11(6):424–432.
- Richardson DW, Dodge GR. Dose-dependent effects of corticosteroids on the expression of matrix-related genes in normal and cytokine-treated articular chondrocytes. Inflamm Res. 2003;52(1):39–49.
- Tsark EC, Wang W, Teng Y-C, Arkfeld D, Dodge GR, Kovats S. Differential MHC class II-mediated presentation of rheumatoid arthritis autoantigens by human dendritic cells and macrophages. J Immunol. 2002;169(11):6625–6633.
- Estrada LE, Dodge GR, Richardson DW, Farole A, Jimenez SA. Characterization of a biomaterial with cartilage-like properties expressing type X collagen generated in vitro using neonatal porcine articular and growth plate chondrocytes. Osteoarthritis Cartilage. 2001;9(2):169–177.
- Noyszewski EA, Wroblewski K, Dodge GR, et al. Preferential incorporation of glucosamine into the galactosamine moieties of chondroitin sulfates in articular cartilage explants. Arthritis Rheum. 2001;44(5):1089–1095.
- Fang Q, Sun YY, Cai W, Dodge GR, Lotke PA, Williams WV. Cartilage-reactive T cells in rheumatoid synovium. Int Immunol. 2000;12(5):659–669.
- Richardson DW, Dodge GR. Effects of interleukin-1beta and tumor necrosis factor-alpha on expression of matrix-related genes by cultured equine articular chondrocytes. Am J Vet Res. 2000;61(6):624–630.
- Dodge GR, Diaz A, Sanz-Rodriguez C, Reginato AM, Jimenez SA. Effects of interferon-gamma and tumor necrosis factor alpha on the expression of the genes encoding aggrecan, biglycan, and decorin core proteins in cultured human chondrocytes. Arthritis Rheum. 1998;41(2):274–283.
- Dodge GR, Hawkins D, Boesler E, Sakai L, Jimenez SA. Production of cartilage oligomeric matrix protein (COMP) by cultured human dermal and synovial fibroblasts. Osteoarthritis Cartilage. 1998;6(6):435–440.
- Richardson DW, Dodge GR. Molecular characteristics of equine stromelysin and the tissue inhibitor of metalloproteinase 1. Am J Vet Res. 1998;59(12):1557–1562.
- Jimenez SA, Ala-Kokko L, Prockop DJ, Merryman CF, Shepard N, Dodge GR. Characterization of human type II procollagen and collagen-specific antibodies and their application to the study of human type II collagen processing and ultrastructure. Matrix Biol. 1997;16(1):29–39.
- Jordan-Sciutto KL, Logan TJ, Norton PA, Derfoul A, Dodge GR, Hall DJ. Reduction in fibronectin expression and alteration in cell morphology are coincident in NIH3T3 cells expressing a mutant E2F1 transcription factor. Exp Cell Res. 1997;236(2):527–536.
- Richardson DW, Dodge GR. Cloning of equine type II procollagen and the modulation of its expression in cultured equine articular chondrocytes. Matrix Biol. 1997;16(2):59–64.
- Dodge GR, Boesler EW, Jimenez SA. Expression of the basement membrane heparan sulfate proteoglycan (perlecan) in human synovium and in cultured human synovial cells. Lab Invest. 1995;73(5):649–657.
- Murdoch AD, Dodge GR, Cohen I, Tuan RS, Iozzo RV. Primary structure of the human heparan sulfate proteoglycan from basement membrane (HSPG2/perlecan). A chimeric molecule with multiple domains homologous to the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor. J Biol Chem. 1992;267(12):8544–8557.
- Dodge GR, Kovalszky I, Hassell JR, Iozzo RV. Transforming growth factor beta alters the expression of heparan sulfate proteoglycan in human colon carcinoma cells. J Biol Chem. 1990;265(29):18023–18029.
- Iozzo RV, Kovalszky I, Hacobian N, Schick PK, Ellingson JS, Dodge GR. Fatty acylation of heparan sulfate proteoglycan from human colon carcinoma cells. J Biol Chem. 1990;265(32):19980–19989.
