Nicholas J. Petrelli, M.D., FACS
Adjunct Professor
Bank of America Endowed Medical Director, Helen F. Graham Cancer Center, Christiana Care Health Services
Professor of Surgery, Thomas Jefferson University
Petrelli
Phone: (302) 623-4550
Fax: (302) 623-4554
Email: npetrelli@christianacare.org
Address:
Helen F. Graham Cancer Center
4701 Ogletown Stanton Road
Suite 1233
Newark, DE 19713
Education
- A.B. - University of Notre Dame
- M.D. - Tulane Medical School
Research Interests
My research interests are in the early detection and primary and secondary prevention of colorectal cancer. This is inclusive of establishing a program where individuals from high risk cancer families can undergo genetic counseling for potential genetic testing and subsequently undergo increase surveillance, prophylactic surgery or chemopreventive therapy. I also collaborate with researchers at the University of Delaware on projects related to development of biomarkers for studying cancer progression and metastasis, and for development of new chemotherapeutic agents targeting metastatic cancers.
Current Projects
- AstraZeneca, Early Detection of Lung Cancer
- NIH, Heparan Sulfate Proteoglycans in Bone Stromal Metastases (with Mary C. Farach-Carson)
- NIH/NCI, Chair, NSABP Colorectal Committee
- NCI, NCI Community Cancer Centers Program
Selected Publications
- Bartos JD, Gaile DP, McQuaid DE, et al. aCGH local copy number aberrations associated with overall copy number genomic instability in colorectal cancer: coordinate involvement of the regions including BCR and ABL. Mutat Res. 2007;615(1-2):1–11.
- Brenner BM, Stoler DL, Rodriguez L, et al. Allelic losses at genomic instability-associated loci in villous adenomas and adjacent colorectal cancers. Cancer Genet Cytogenet. 2007;174(1):9–15.
- Esquivel J, Sticca R, Sugarbaker P, et al. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the management of peritoneal surface malignancies of colonic origin: a consensus statement. Society of Surgical Oncology. Ann Surg Oncol. 2007;14(1):128–133.
- Khatri VP, Chee KG, Petrelli NJ. Modern multimodality approach to hepatic colorectal metastases: solutions and controversies. Surg Oncol. 2007;16(1):71–83.
- Kuebler JP, Wieand HS, O'Connell MJ, et al. Oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: results from NSABP C-07. J Clin Oncol. 2007;25(16):2198–2204.
- Metreveli RE, Sahm K, Abdel-Misih R, Petrelli NJ. Major pancreatic resections for suspected cancer in a community-based teaching hospital: lessons learned. J Surg Oncol. 2007;95(3):201–206.
- O'Dwyer PJ, Eckhardt SG, Haller DG, et al. Priorities in colorectal cancer research: recommendations from the Gastrointestinal Scientific Leadership Council of the Coalition of Cancer Cooperative Groups. J Clin Oncol. 2007;25(16):2313–2321.
- Smith JF, Mahmood S, Song F, et al. Identification of DNA methylation in 3' genomic regions that are associated with upregulation of gene expression in colorectal cancer. Epigenetics. 2007;2(3):161–172.
- Bartlett DL, Berlin J, Lauwers GY, Messersmith WA, Petrelli NJ, Venook AP. Chemotherapy and regional therapy of hepatic colorectal metastases: expert consensus statement. Ann Surg Oncol. 2006;13(10):1284–1292.
- Datta RV, Petrelli NJ, Ramzy J. Evaluation and management of incidentally discovered thyroid nodules. Surg Oncol. 2006;15(1):33–42.
- Frelick R, Strusowski T, Grusenmeyer P, Petrelli N. Oncology nurse care coordinators as navigators improving cancer disease management and the patient experience. Oncol Issues. 2006;21(4):26–30.
- Grusenmeyer P, Petrelli N, Strusowski P. Developing and operating multidisciplinary disease specific clinics. Community Oncol. 2006;3(6):26.
- Khatri VP, Shah MH, Petrelli NJ, et al. Type-2 dominant cytokine gene expression following hepatic surgery. J Hepatobiliary Pancreat Surg. 2006;13(5):442–449.
- Lembersky BC, Wieand HS, Petrelli NJ, et al. Oral uracil and tegafur plus leucovorin compared with intravenous fluorouracil and leucovorin in stage II and III carcinoma of the colon: results from National Surgical Adjuvant Breast and Bowel Project Protocol C-06. J Clin Oncol. 2006;24(13):2059–2064.
- Perkins RS, Sahm K, Marando C, et al. Analysis of Epstein-Barr virus reservoirs in paired blood and breast cancer primary biopsy specimens by real time PCR. Breast Cancer Res. 2006;8(6):R70.
- Petrelli N. Surgical management of liver metastases from colorectal cancer. Clin Adv Hematol Oncol. 2006;4(9):673–675.
- Petrelli NJ. Expressing the prochemotherapy position on treatment of synchronous colorectal metastases in the asymptomatic patient. Ann Surg Oncol. 2006;13(2):137–139.
- Swede H, Bartos JD, Chen N, et al. Genomic profiles of colorectal cancers differ based on patient smoking status. Cancer Genet Cytogenet. 2006;168(2):98–104.
- Desch CE, Benson AB 3rd, Somerfield MR, et al. Colorectal cancer surveillance: 2005 update of an American Society of Clinical Oncology practice guideline. J Clin Oncol. 2005;23(33):8512–8519.
- Khatri VP, Petrelli NJ, Belghiti J. Extending the frontiers of surgical therapy for hepatic colorectal metastases: is there a limit? J Clin Oncol. 2005;23(33):8490–8499.
- Metreveli RE, Sahm K, Denstman F, Abdel-Misih R, Petrelli NJ. Hepatic resection at a major community-based teaching hospital can result in good outcome. Ann Surg Oncol. 2005;12(2):133–137.
- Petrelli NJ, Abbruzzese J, Mansfield P, Minsky B. Hepatic resection: the last surgical frontier for colorectal cancer. J Clin Oncol. 2005;23(20):4475–4477.
- Rousseau DLJ, Thomas CRJ, Petrelli NJ, Kahlenberg MS. Squamous cell carcinoma of the anal canal. Surg Oncol. 2005;14(3):121–132.
- Bartos JD, Stoler DL, Matsui S-ichi, et al. Genomic heterogeneity and instability in colorectal cancer: spectral karyotyping, glutathione transferase-Ml and ras. Mutat Res. 2004;568(2):283–292.
- Pandya KJ, Lefkopoulou M, Petrelli NJ, et al. Phase II study of cisplatin and 5-fluorouracil (PF) and mitomycin C, vincristine, cisplatin and 5-fluorouracil (MVPF) in patients with metastatic large bowel cancer: an Eastern Cooperative Oncology Group study (EST 1285). Oncology. 2004;66(2):118–125.
