Sigrid Rajasekaran, Ph.D.
Head, Cancer Cell Metabolism Laboratory, A.I. duPont Hospital for Children
Rajasekaran
Phone: (302) 651-6538
Fax: (302) 651-6539
Email: sraj@medsci.udel.edu
Address:
Cancer Cell Metabolism Laboratory
Rockland Center I-230
Department of Biomedical Research
A.I. duPont Hospital for Children
1600 Rockland Road
Wilmington, DE 19803
Education
- B.S. - Universtity of Ulm (Germany)
- Ph.D. - Cornell University
Nemours Education and Research Program
An Alliance to Foster Biomedical Research Between the Department of Biological Sciences at the University of Delaware and Nemours Biomedical Research at the Alfred I. duPont Hospital for Children/Nemours Children's Clinic
Research Interests
- Link between obesity and cancer
- Therapeutic and diagnostic potential of intracellular sodium
Current Projects
- Regulation of metabolic pathways by intracellular ions in obesity and cancer
- Intracellular ion homeostasis dependent regulation of signaling pathways
Research Group
- Daniel Wolle - Research Assistant. Studying the effects of intracellular sodium on signaling pathways.
Selected Publications
- Seligson DB, Rajasekaran SA, Yu H, et al. Na,K-adenosine triphosphatase alpha1-subunit predicts survival of renal clear cell carcinoma. J Urol. 2008;179(1):338–345.
- Barwe SP, Kim S, Rajasekaran SA, Bowie JU, Rajasekaran AK. Janus model of the Na,K-ATPase beta-subunit transmembrane domain: distinct faces mediate alpha/beta assembly and beta-beta homo-oligomerization. J Mol Biol. 2007;365(3):706–714.
- Rajasekaran SA, Barwe SP, Gopal J, Ryazantsev S, Schneeberger EE, Rajasekaran AK. Na-K-ATPase regulates tight junction permeability through occludin phosphorylation in pancreatic epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2007;292(1):G124–33.
- Barwe SP, Rajasekaran SA, Rajasekaran AK. Identification of protein kinase C as an intermediate in Na,K-ATPase beta-subunit mediated lamellipodia formation and suppression of cell motility in carcinoma cells. Cell Mol Biol (Noisy-le-Grand). 2006;52(8):41–47.
- Barwe SP, Anilkumar G, Moon SY, et al. Novel role for Na,K-ATPase in phosphatidylinositol 3-kinase signaling and suppression of cell motility. Mol Biol Cell. 2005;16(3):1082–1094.
- Kim G, Rajasekaran SA, Thomas G, et al. Renal clear-cell carcinoma: an ultrastructural study on the junctional complexes. Histol Histopathol. 2005;20(1):35–44.
- Rajasekaran SA, Barwe SP, Rajasekaran AK. Multiple functions of Na,K-ATPase in epithelial cells. Semin Nephrol. 2005;25(5):328–334.
- Espineda CE, Chang JH, Twiss J, Rajasekaran SA, Rajasekaran AK. Repression of Na,K-ATPase beta1-subunit by the transcription factor snail in carcinoma. Mol Biol Cell. 2004;15(3):1364–1373.
- Rajasekaran SA, Gopal J, Espineda C, Ryazantsev S, Schneeberger EE, Rajasekaran AK. HPAF-II, a cell culture model to study pancreatic epithelial cell structure and function. Pancreas. 2004;29(3):e77–83.
- Rajasekaran SA, Gopal J, Willis D, Espineda C, Twiss JL, Rajasekaran AK. Na,K-ATPase beta1-subunit increases the translation efficiency of the alpha1-subunit in MSV-MDCK cells. Mol Biol Cell. 2004;15(7):3224–3232.
- Rajasekaran AK, Rajasekaran SA. Role of Na-K-ATPase in the assembly of tight junctions. Am J Physiol Renal Physiol. 2003;285(3):F388–96.
- Rajasekaran SA, Hu J, Gopal J, et al. Na,K-ATPase inhibition alters tight junction structure and permeability in human retinal pigment epithelial cells. Am J Physiol Cell Physiol. 2003;284(6):C1497–507.
- Rajasekaran SA, Palmer LG, Moon SY, et al. Na,K-ATPase activity is required for formation of tight junctions, desmosomes, and induction of polarity in epithelial cells. Mol Biol Cell. 2001;12(12):3717–3732.
- Rajasekaran SA, Palmer LG, Quan K, et al. Na,K-ATPase beta-subunit is required for epithelial polarization, suppression of invasion, and cell motility. Mol Biol Cell. 2001;12(2):279–295.
- Rajasekaran SA, Ball WJJ, Bander NH, Liu H, Pardee JD, Rajasekaran AK. Reduced expression of beta-subunit of Na,K-ATPase in human clear-cell renal cell carcinoma. J Urol. 1999;162(2):574–580.
