Department of Biological Sciences: Leading the way to Prominence
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Research Programs

An alphabetical list of faculty and their research areas is also available.

Animal Physiology
Name Description
Akins, Robert Development and regulation of cellular organization and function in striated muscle.
DeLeon, Patricia Reproductive genetics, genomics, and sperm proteomics.
Duncan, Melinda Eye development.
Duncan, Randall Signal transduction of mechanical and hormonal stimulation in the development and maintenance of bone and cartilage.
Farach-Carson, Mary Molecular and cell biology of bone cells and bone extracellular matrix.
Hobson, Grace Progression of diseases of myelin production in the central nervous system.
Kirn-Safran, Catherine Skeletogenesis in mice.
Laverty, Gary Epithelial transport systems in cultured tissues.
Moore, Michael Neuroendocrine control of reproductive behavior and aggression, stress physiology and maternal influences on offspring phenotype.
Naik, Ulhas Role of adhesion molecules in vascular biology.
Nohe, Anja Role of bone morphogenetic proteins (BMPs) during skeletal development and maintenance.
Rajasekaran, Ayyappan Regulation of epithelial junctional complexes by ion transporters and cell adhesion molecules.
Rajasekaran, Sigrid Link between obesity and cancer.
Schanen, N. Carolyn Cellular mechanisms regulating expression and function of chromatin proteins in nerve and bone cells.
Sikes, Robert Mouse prostate development and the development and progression of human prostate cancer.
Twiss, Jeffery Effects of neuronal activity and environmental stimuli on nerve regeneration and neural repair.
Usher, David The relationship of obesity to metabolic syndrome and heart disease.
Wagner, Roger The role of pericytes and endothelial cells in the function of microvessels and capillaries.
Wang, Wenlan Cell death in a pediatric motor neuron disorder.
Cancer Biology
Name Description
Boman, Bruce Colon cancer stem cell research.
Cooper, Carlton The role of cell adhesion in prostate cancer preferential metastasis to bone.
Dodge, George Role of extracellular matrix and their proteases in cancer, cell migration and apoptosis.
Farach-Carson, Mary Extracellular matrix and hormonal influences on cancer metastasis to bone.
Galileo, Deni Adhesion molecules that influence glioma and breast cancer cell motility, invasiveness, and metastasis in a chick xenograft model.
Mason, Robert Mechanisms of cell death in treatment of neuroblastoma.
McLane, Mary Ann Molecular mechanisms involved in cancer metastasis.
Naik, Ulhas Tumor angiogenesis and tumor metastasis using animal models, focusing on breast and prostate cancer.
Nohe, Anja Role of vitamin D and bone morphogenetic proteins (BMPs) in breast cancer.
Parcells, Mark Cancer vaccines and tumor immunology.
Rajasekaran, Ayyappan Molecular mechanisms involved in the regulation of epithelial to mesenchymal and mesenchymal to epithelial transitions.
Rajasekaran, Sigrid Link between obesity and cancer.
Sikes, Robert Human prostate cancer progression, metastatic cell interaction with bone and therapeutic intervention.
Simmons, Daniel Malignant transformation by papovaviruses.
Sol-Church, Katia Mechanisms of chemotherapeutic resistance in osteosarcoma.
van Golen, Kenneth Role of RhoC GTPase in conferring a metastatic phenotype to aggressive cancers.
Wu, Cathy Bioinformatics and computation biology of cancer biology.

See also our partners in translational cancer research at the Christiana Care Cancer Research Program.

Cell and Extracellular Matrix Biology
Name Description
Akins, Robert Cell:cell interactions, signaling cascades, and cell migration in tissue engineering and regenerative therapies.
Boman, Bruce Colon cancer stem cell research.
Cooper, Carlton The role of cell adhesion in prostate cancer preferential metastasis to bone.
Czymmek, Kirk Fungal cell biology.
Dodge, George Cartilage extracellular matrix, tissue engineering of cartilage and bone substitutes.
Duncan, Melinda The function of the lens capsule and the regulation of transcription by cell signaling.
Duncan, Randall Signal transduction of mechanical and hormonal stimulation in the development and maintenance of bone and cartilage.
Farach-Carson, Mary Molecular and cell biology of bone cells and bone extracellular matrix.
Galileo, Deni Cell division, death, migration, and differentiation in early development of the vertebrate brain; cancer cell biology and interaction with ECM.
Kirn-Safran, Catherine Osteoblast, chondrocyte, and odontoblast differentiation.
Laverty, Gary Epithelial transport systems in cultured tissues.
Naik, Ulhas Signaling through adhesion molecules during angiogenesis and platelet aggregation.
Nohe, Anja Role of bone morphogenetic proteins (BMPs) and vitamin D during mesenchymal stem cell differentiation.
Rajasekaran, Ayyappan Modulation of tumor microenvironment by cell adhesion molecules.
Rajasekaran, Sigrid Therapeutic and diagnostic potential of intracellular sodium.
Selva, Erica Genetic and molecular control of signal transduction during Drosophila development.
Sherrier, D. Janine Modification of the plant cell wall during interactions with microbes.
Sikes, Robert Mouse prostate development and the development and progression of human prostate cancer.
Wang, Wenlan Cell death in a pediatric motor neuron disorder.
Wu, Cathy Bioinformatics and computation biology of cell and extracellular matrix biology.
Developmental Biology
Name Description
Akins, Robert Cardiac morphogenesis and the development of congenital heart malformations.
DeLeon, Patricia Genetics of sperm maturation and function.
Dodge, George Extracellular matrix gene expression in development of the skeleton; cartilage development.
Duncan, Melinda Eye development.
Duncan, Randall Signal transduction of mechanical and hormonal stimulation in the development and maintenance of bone and cartilage.
Farach-Carson, Mary Bone and cartilage formation.
Galileo, Deni Early vertebrate brain development.
Hobson, Grace Gene expression during brain development.
Kirn-Safran, Catherine Mineralized tissue embryogenesis.
Mason, Robert Role of lysosomal proteases in placental development.
Molloy, George Transcriptional and translational control in brain development.
Naik, Ulhas Cardiac development and hypertrophy.
Nohe, Anja Mechanisms of skeletal development.
Rajasekaran, Ayyappan Role of epithelial junctional complexes and ion transporters in development.
Selva, Erica Control of Wnt and hedgehog signaling in Drosophila development.
Sherrier, D. Janine Development of nitrogen-fixing root nodules; development of pathogenic root knots.
Sikes, Robert Development of the prostate gland.
Twiss, Jeffery Axon growth mechanisms and neuronal survival/signaling.
Usher, David Development of adipose tissue.
Ecology and Evolution
Name Description
Boyd, E. Fidelma Molecular evolution and pathogenesis of bacteria.
Duncan, Melinda Evolutionary origins of refractive proteins.
Hanson, Thomas Evolution of autotrophy, tundra soil microbial ecology, metaproteomics/genomics.
McDonald, John Effects of natural selection on nuclear genes.
Moore, Michael Ecological immunology and the tradeoffs between immune and reproductive systems.
Parcells, Mark The evolution of herpesvirus virulence.
Smith, David Sulfur and nitrogen cycles in bacteria residing in salt marsh environments.
Tallamy, Douglas Luperine chrysomelid beetle interactions with toxic cucurbitacin triterpenes.
Microbiology and Virology
Name Description
Boyd, E. Fidelma Molecular evolution and pathogenesis of bacteria.
Czymmek, Kirk Fungal cell biology.
Galileo, Deni Retroviruses and their use as vectors, including lentiviruses.
Hanson, Thomas Photosynthetic metabolism, biogeochemistry, applied microbiology.
Herson, Diane Physiology of organisms which carry out bioremediation, Helicobacter-pylori in water.
Keeler, Calvin Avian influenza and avian herpesviruses - host-pathogen interactions, vaccines, and diagnostics.
Parcells, Mark Molecular virology of Marek's disease virus (MDV), an oncogenic herpesvirus of chickens.
Parent, Michelle Yersinia - host-pathogen interaction.
Schmidt, Carl Pathogenesis of oncogenic herpes viruses.
Sherrier, D. Janine The role of bacterial LPS in nitrogen-fixing root nodule development.
Simmons, Daniel Mechanism of DNA replication.
Smith, David Sulfur and nitrogen cycles in bacteria residing in salt marsh environments.
Wommack, K. Eric Viruses and their impact on microbial communities.
Wu, Cathy Bioinformatics and computation biology of microbiology and virology.
Molecular Biology and Genetics
Name Description
Akins, Robert Heterotypic cell interactions in the control of gene expression, multi-cellular organization, and contractile function in striated muscle.
Boman, Bruce Colon cancer stem cell research.
Boyd, E. Fidelma Molecular evolution and pathogenesis of bacteria.
Czymmek, Kirk Fungal cell biology and plant pathogenesis.
DeLeon, Patricia Reproductive genetics, genomics, and sperm proteomics.
Dodge, George Chondrocyte gene regulation and disease, alternative-splicing of ECM genes.
Duncan, Melinda The transcriptional consequences of cell signaling during development.
Farach-Carson, Mary Molecular and cell biology of bone cells and bone extracellular matrix.
Galileo, Deni Migration, survival, and differentiation of vertebrate brain and of brain tumor cells.
Hanson, Thomas Genetic analysis of metabolism, expanding genetic toolkits in novel microbes.
Herson, Diane Physiology of organisms which carry out bioremediation, Helicobacter-pylori in water.
Hobson, Grace Splicing mechanisms and genomic copy number variation.
Keeler, Calvin Genomic approaches to the study of the innate immune system.
Kirn-Safran, Catherine Gene targeting by homologous recombination.
McLane, Mary Ann Molecular mechanisms involved in cancer metastasis.
Molloy, George Control of animal cell growth and differentiation related to neuronal and brain glial cells.
Morgan, Robin Molecular biology of Marek's disease.
Naik, Ulhas Signaling cross-talk between growth factor receptors and adhesion molecules: use of transgenic and knockout mice.
Nohe, Anja Utilizing genetic mouse models of peak bone density to determine the mechanism underlying peak bone mass.
Parcells, Mark Functional analysis of Marek's disease virus (MDV) gene products.
Rajasekaran, Ayyappan Role of Na,K-ATPase in cell signaling.
Schanen, N. Carolyn Genetics of autism and speech disorders, epigenetic regulation of gene expression by DNA methylation, chromosomal rearrangements.
Schmidt, Carl Bioinformatics and avian genomics.
Selva, Erica Genetic and molecular control of signal transduction during Drosophila development.
Sherrier, D. Janine Analysis of the small RNA transcriptome of Medicago truncatula.
Sikes, Robert Mouse prostate development and the development and progression of human prostate cancer.
Simmons, Daniel Mechanism of DNA replication.
Sol-Church, Katia Genetics of Costelo Syndrome.
Twiss, Jeffery Subcellular localization of neuronal mRNAs and translational control.
Usher, David The relationship of obesity to metabolic syndrome and heart disease.
Wang, Wenlan Cell death in a pediatric motor neuron disorder.
Wu, Cathy Bioinformatics and computation biology of molecular biology and genetics.
Science Education
Name Description
Allen, Deborah Active and collaborative learning strategies and materials; learning communities.
Fifield, Steven Cultural studies of science; how knowledge, meaning, and identity are enacted in science education.
Hodson, Robert Biology education with special emphasis on development of introductory biology laboratory investigations and computer networking.
Schmieg, Florence The effect of Problem-Based-Learning (PBL) strategies on educational outcomes.
Usher, David Affect of undergraduate research on educational outcomes; recruitment and retention of underrepresented minorities in the sciences.
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