Gary H. Laverty, Ph.D.

Teaching

*Course web site available through MyCourses

Research Interests

Current research is directed toward studies of epithelial ion and organic substrate transport. Primary cell cultures and established cell lines of renal and intestinal epithelia are used to investigate hormonal and dietary control of transport processes. Cells are grown as monolayers on permeable membrane filters, achieving a high degree of epithelial polarity and differentiation. These monolayers can then be mounted in modified flux chambers (Ussing chambers) for study by electrophysiological methods, isotopic flux measurements or other analytical methods. Much of this work is comparative in nature, focusing on unique or unusual transport processes in birds or other non-mammalian groups. Two major projects are currently under investigation in primary cultures of the renal proximal tubule. One involves a chloride secretion pathway, mediated by a cystic fibrosis transmembrane regulator (CFTR)-like chloride channel that is stimulated by parathyroid hormone. The second project involves a study of a sodium-linked vitamin C (ascorbic acid) transporter in these cells. Antioxidants, such as vitamin C, may be particularly important in birds because of levels of oxidative stress. Immunoblotting and PCR methods are also used to look at protein and mRNA expression levels of these epithelial transporters, thus complementing the electrophysiological functional assays.

Selected Publications

Associate Professor

Phone: (302) 831-8180

Fax: (302) 831-2281

Email: laverty@udel.edu

Office: 244 Wolf Hall

Lab: 247 Wolf Hall

Address:
Department of Biological Sciences
Wolf Hall
University of Delaware
Newark, DE 19716

Education

  • B.S. - Lowell Technological Institute
  • Ph.D. - University of Connecticut
  • Postdoctoral - University of Arizona Health Sciences Center