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Ulhas P. Naik, Ph.D.
- BISC 675 - Cardiovascular Physiology
The top two killers of human beings are cardiovascular disease and cancer. Our research interest is focused on developing therapeutic strategies to interrupt the progress of these dreadful diseases. In this regard, we have identified several novel gene products that play key regulatory roles in the progression of cardiovascular diseases and cancer. Calcium- and integrin-binding protein family and junctional adhesion molecule family members are some such proteins currently being studied in the laboratory. Using cell and molecular biological approaches, we have characterized the potential role of these proteins in physiological and pathological settings. Cutting edge technologies, such as the yeast two-hybrid system, siRNA, and transgenic mouse models are routinely employed in the laboratory. Several in vivo animal models for evaluating cardiovascular diseases and cancer are established in the laboratory and are routinely used to evaluate the roles of a variety of proteins suspected to be involved in the onset and progression of cardiovascular diseases and cancer. We are also using multidisciplinary bioengineering tools such as systems biology, nanotechnology, and fluid dynamics modeling to develop specific strategies in order to understand, evaluate, and control cardiovascular diseases and cancer. The laboratory is fully equipped with state-of-the-art instrumentation to perform the above-mentioned experiments.
Some specific projects involve:
- Positive and negative regulatory mechanisms of platelet activation during thrombosis
- Mechanism of new blood vessel formation (angiogenesis) during ischemia and cancer
- Mechanism of breast and prostate cancer cell metastasis
- Use of nanotechnology to deliver drugs to specifically targeted sites.
Fraunhofer-UD Research Grant
Meghna U. Naik, M.Sc. - Research Scientist
Zhiying Zou, Ph.D. - Research Associate
Karen Fong, Ph.D. - Research Associate
Ritu Sharma, Ph.D. - Postdoctoral Fellow
Vilas Desai, Ph.D. - Postdoctoral Fellow
Kalyan Golla, Ph.D. - Postdoctoral Fellow
Chia-Hung Tsai, Ph.D. - Graduate Student
Randall Derstine, Ph.D. - Graduate Student
Sandhya Ramachandran, M.S. - Graduate Student
Joshua Barton - Undergraduate Research Scholar
Kaitlyn Thomesen - Undergraduate Research Scholar
- Manne, B.K., Getz, T.M., Alshehri, O., Hughes, C.E., Dangelmaier, C., Naik, U.P., Watson, S.P., Kunapuli, S.P. Fucoidan is a novel platelet agonist for the CLEC-2 receptor. J. Biol. Chem. 2013. 288:7717-26.
- Chatterjee, S., Wang, Y., Duncan, M.K., and Naik, U.P. Junctional Adhesion Molecule-A Regulates Vascular Endothelial Growth Factor Receptor-2 Signaling-dependent Mouse Corneal Wound Healing. PLoS One. 2013. 8(5):e63674
- Naik, M.U., Caplan, J.L. and Naik, U.P. Junctional adhesion molecule-A suppresses platelet integrin ±IIb≤3 signaling by recruiting Csk to the integrin-c-Src complex. Blood. 2013. In press. PMID: 24300854. Cover art, Faculty1000 recommendation, and Editorial commentary.
- Lathia, J.D., Li, M., Sinyuk, M., Alvarado, A.G., Flavahan, W.A., Stoltz, K., Rosager, A.M., Hale, J., Hitomi, M., Gallagher, J., Wu, Q., Martin, J., Vidal, J.G., Nakano, I., Dahlrot, R.H., Hansen, S., McLendon, R.E., Sloan, A.E., Bao, S., Hjelmeland, A.B., Carson, C.T., Naik, U.P., Kristensen, B. and Rich. J.N. High-throughput flow cytometry screening reveals a role for junctional adhesion molecule A as a cancer stem cell maintenance factor. Cell Rep. 2014. 6(1):117-29. PMID: 24373972.
- Aravindan, R.G., Fomin, V., Naik, U.P., Modelsky, M., Naik, M.U., Galileo, D.S. Duncan, R. Martin-DeLeon, P.A. CASK Interacts with PMCA4b and JAM-A on the Mouse Sperm Flagellum to Regulate Ca2+ Homeostasis and Motility. J. Cellular Physiol. 2012. 227(8):3138-50.
- Kostyak, J.C., Naik, M.U., and Naik, U.P. Calcium- and integrin-binding protein 1 regulates megakaryocyte ploidy, adhesion, and migration. Blood. 2012. 119(3):838-46.
- Naik, M.U. Stalker, T. Brass, L.F. and Naik, U.P. JAM-A Protects from Thrombosis by Suppressing Integrin aIIbb3-dependent Outside-in Signaling in Platelets. Blood 2012. 119(14):3352-60.
- Chatterjee, S. and Naik, U.P. Pericyte-endothelial cell interaction: A survival mechanism for the tumor vasculature. Cell Adhesion and Migration 2012. 6(3):157-9.
- Lakshmi, S.P., Reddy, A.T., Naik, M.U., Naik, U.P. and Reddy, R.C. Effect of JAM-A Deficiency or Blocking antibodies on Neutrophil Migration and Lung Injury in a Murine Model of Ali. Am. J. of Phys. Lung Cell Mol. Physiol. 2012. Aug. 17.
- Welf ES, Naik UP, Ogunnaike BA. A spatial model for integrin clustering as a result of feedback between integrin activation and integrin binding. Biophys. J. 2012 Sep 19;103(6):1379-89. doi: 10.1016/j.bpj.2012.08.021. PMID:22995511
- Naik, M.U. and Naik, U.P. Contra-regulation of calcium- and integrin-binding protein 1-induced cell migration on fibronectin by PAK1 and MAP kinase signaling. J. Cellular Biochem. 2011. 112(11):3289-99.
- Welf, E.S., Naik, U.P., and Ogunnaike, B.A. Probabilistic modeling and analysis of the effect of extracellular matrix density on the sizes, shapes, and locations of integrin clusters in adherent cells. BMC Biophysics 2011. 4:15.
- Johnson, D.A., Spaeth, J.R., Rose, W.C., Naik, U.P. and Beris, A.N. An impedance model for blood flow in the human arterial system. Part 1: Model development and MATLAB implementation. Computers & Chemical Engineering. 2011.35(7):1304-16.
- Johnson, D.A., Naik, U.P. and Beris, A.N. Efficient implementation of the proper outlet flow conditions in blood flow simulations through asymmetric arterial bifurcations. Int. J. Numerical Methods in Fluids. 2011. 66:1383-1408.
- Johnson, D.A., Rose, W.C., Edwards, J.W., Naik, U.P. and Beris, A.N. Application of 1D blood flow models of the human arterial network to differential pressure predictions. J. Biomech. 2011. 44(5): 869-76.
- Kostyak, J.C. and Naik U.P. CIB1 regulates endomitosis via an interaction with the mitotic kinase Plk3. PLoS One 2011. 6(1): e14513.
- Chari-Turaga, R. and Naik, U.P. Integrin IIb3 - a novel effector of G13. Cell Adhesion and Migration, 2011. 5(1):4-5.
- Naik, M.U. and Naik, U.P. Calcium- and integrin-binding protein 1 regulates microtubule organization and centrosome segregation through Polo-like kinase 3 during cell cycle progression. Int. J. Biochem. Cell Biol. 2011. 43(1):120-9.
- Naik, M.U., Pham, N., Beebe, K., Dai, W. and Naik, U.P. Calcium-dependent inhibition of Plk3 activity by CIB1 in breast cancer cells. Int. J. Cancer 2011. 128(3):587-96.
- Naik UP. PTEN: not just a tumor suppressor. Blood. 2010;116:2404–5.
- Millili PG, Naik UP, Sullivan MO. Multiscale experimental biolody and nucleic acid delivery: Cancer therapeutic approaches via rational formulation design. Cancer Therapy. 2009;7:429–448.
- Naik MU, Nigam A, Manrai P, et al. CIB1 deficiency results in impaired thrombosis: the potential role of CIB1 in outside-in signaling through integrin alpha(iib)beta(3). J Thromb Haemost. 2009;7:1906–14.
- Naik UP. Lyn and PKCdelta order SHIP1 embargo. Blood. 2009;114:2886–7.
- Welf ES, Ogunnaike BA, Naik UP. A quantitative statistical description of integrin clusters in adherent cells. IET Syst Biol. 2009;3:307–16.
- Yoon KW, Kang Y-H, Lee JK, et al. CIB1 functions as a Ca2+-sensitive modulator of stress-induced signaling by targeting ASK1. Proc Natl Acad Sci U S A. 2009;106:17389–94.
Director, Delaware Cardiovascular Research Center
Phone: (302) 831-0434
Fax: (302) 831-2281
Office: 309 Wolf Hall
Lab: 256-259 Wolf Hall
Cardiovascular and Cancer Biology Laboratory
Department of Biological Sciences
256 Wolf Hall
University of Delaware
Newark, DE 19716
- B.S., M.S., Ph.D. - University of Bombay (India)
- Postdoctoral - Cornell University Medical College
- Postdoctoral - SUNY Health Science Center at Brooklyn