Oyenike ‘Nike’ Olabisi, Ph.D.

Teaching

BISC 207- Introductory Biology (cell and molecular biology), Multiple sections

This course focuses on the molecular and cellular basis of life.  The goal is to provide students with scientific thinking skills regardless of their chosen discipline. Students develop an appreciation of the relationship between cellular structure and function; the significance of signal transduction pathways, energy acquisition and transformation; cell division including Mendelian genetics and the flow of genetic information from DNA to RNA to proteins. 

The laboratory course emphasizes application of the scientific method, hypothesis based experimentation, data analysis and scientific writing in addition to fundamental laboratory techniques.

Research Interests

My research training and interests are in Cancer research.  I investigated cell signaling pathways and the molecular mechanisms underlying cellular transformation and metastasis.  Specifically, I studied the contributions of c-myc onco-protein to the resistance of melanoma cells to transforming growth factor beta (TGF-β) tumor suppression. Currently, I am adopting innovative scientific teaching methods including active learning and problem based learning strategies to undergraduate biology instruction.
 

Selected Publications

  • Non-Canonical Smads Phosphorylation Induced by the Glutamate Release Inhibitor, Riluzole, through GSK3 Activation in Melanoma. Abushahba W, Olabisi OO, Jeong B-S, Boregowda RK, Wen Y, et al. (2012) PLoS ONE 7(10): e47312. doi:10.1371/journal.pone.0047312
  • Olabisi, O., Mahon, G., Kostenko, E., Liu, Z., Ozer H., and Whitehead, I. (2006) Bcr interacts with components of the ESCRT-I complex and is required for epidermal growth factor receptor turnover. Cancer Research, 66(12):6250-7.
  • Kostenko, E., Olabisi, O., Rodriguez, P., and Whitehead, I. (2006) Identification of a novel scaffold protein that links Src kinase to Rho protein signaling. Molecular Cell Biology 26(23):8964-8975.
  • Liu, Z., Kostenko, E., Mahon, G., Olabisi, O., Whitehead, I. (2006) Transformation by the Rho-specific Guanine Nucleotide Exchange Factor Dbs Requires ROCK I-mediated Phosphorylation of Myosin Light Chain. Journal of  Biological Chemistry, 281(23):16043-51.
  • Rodriguez, PL, Sahay, S, Olabisi, O and Whitehead IP, (2007). ROCK I-mediated activation of NF-kappaB by RhoB.  Cell signal 2007 Nov; 19(11) 2361-9.

Selected Abstracts and Presentations

  • Investigating the role of high c-Myc levels in the resistance to TGFβ-mediated tumor suppression in melanoma. Oyenike Olabisi, Kim Merrigan and Karine Cohensolal. Annual IRACDA meeting NIH-NIGMS- Transforming Undergraduate Science education, June 2011, Houston Texas.
  • Investigating the role of high c-Myc levels in the resistance to TGFβ-mediated tumor suppression in melanoma. Oyenike Olabisi, Kim Merrigan and Karine Cohensolal. Annual Cancer Retreat, NJ Commission for Science and Technology, May 2011, Piscataway, New Jersey.
  • Investigating the role of high c-Myc levels in the resistance to TGFβ-mediated tumor suppression in melanoma. Oyenike Olabisi and Karine Cohensolal. AACR 102 Annual meeting, April 2011, Orlando, Florida.
  • Discovery of Selective Inhibitors of the Kinase and Metastatic Activities of Activated Cdc42-Associated Kinase (ACK1). Oyenike Olabisi, Vladyslav Kholodovych, Alam Nur-E- Kamal, Safirah Stewart-Singleton,  Christina Andaya, Richard Wood and William Welsh. AACR Translational cancer medicine USA, July 2010, San Francisco, CA.
  • Integration of new shape-based descriptors for QSAR applications. Vladyslav Kholodovych, Dmitriy Chekmarev, Jens Erik Pontoppidan Larsen, Oyenike Olabisi, Svava Ósk Jónsdóttir, William Welsh. 18th EuroQSAR Symposium, Sept 2010 Rhodes, Greece.  
  • Bcr Interacts with the ESCRT-1 complex and is required for Epidermal growth factor receptor turnover. Oyenike Olabisi, Gwendolyn M. Mahon, Elena Kostenko, Zhuoming Liu, Harvey L. Ozer and Ian P. Whitehead. The 2007 Annual Retreat on cancer Research by the New Jersey State Commission on Cancer research, May 2007, Piscataway, New Jersey. (Invited Speaker, received the Gallo award for excellence in research and scholarship.)
  • Characterization of the interaction between Bcr and XPB in Chronic Myelogenous Leukemia.  Nicole Pannucci, Oyenike Olabisi, Sutapa Sahay, Gwendolyn Mahon and Ian P. Whitehead.  AACR-JCI.  In the Forefront of Basic and Translational Cancer Research, Jan 2007, Waikoloa, Hawaii.
  • Oyenike Olabisi, Gwendolyn M. Mahon, Elena Kostenko, Zhuoming Liu, Harvey L. Ozer and Ian P. Whitehead (2006). A Novel Function for Bcr in Chronic Myelogenous Leukemia. Keystone Symposia: Cancer Kinases Lessons from the Clinic, February 2006, Santa Fe, New Mexico.
  • Oyenike Olabisi, Gwendolyn M. Mahon, Elena Kostenko, Zhuoming Liu, Harvey L. Ozer and Ian P. Whitehead (2006). Bcr interacts with components of the ESCRT-I complex and is required for epidermal growth factor receptor turnover. New Jersey commission on cancer research annual retreat, May 2006, New Brunswick, New Jersey.
  • Oyenike Olabisi, Gwendolyn M. Mahon, Elena Kostenko, Zhuoming Liu, and Ian P. Whitehead (2005) A Novel Function for Bcr in Chronic Myelogenous Leukemia.  FASEB Summer Research Conference on Hematological Malignancies, August 2005, Saxtons River, Vermont.

Assistant Professor

Phone: (302) 831-1215

Fax: (302) 831-2281

Email: nolabisi@udel.edu

Office: 206 Wolf Hall

Address:
Department of Biological Sciences
Wolf Hall
University of Delaware
Newark, DE 19716

Education

B.Sc. - University of Ibadan, Nigeria

M.S. - Montclair state University, NJ.

Ph.D. -New Jersey Medical School, NJ (NIH-NCI NRSA fellow).

Postdoctoral Training:

UMDNJ- Robert Wood Johnson Medical School, NJ

NIH-IRACDA fellow, the Cancer Institute of New Jersey.