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A not-so-canonical Wnt signaling pathway in development and cancer1A not-so-canonical Wnt signaling pathway in development and cancer318 Wolf Hall9/9/2019 3:00:00 PM9/9/2019 4:00:00 PMMelinda Duncan, Ph.D.Shuo Wei, Ph.D.<p>​The canonical Wnt pathway is a major signaling pathway that plays important roles in development and disease. The Wei Lab is interested in how Wnt signaling is regulated under normal and pathological conditions. We have identified two enzymes, the cellsurface disintegrin metalloproteinase ADAM9 and the intracellular RNA helicase DDX3, as key regulators of Wnt signaling in colon cancer progression and neural crest induction, respectively. Instead of acting on the Wnt ligands and receptors, these enzymes regulate the activity of Akt (protein kinase B) and a crosstalk between Akt and Wnt signaling. Our findings provide important mechanistic insight into the novel function of the tumor-associated antigen ADAM9 in promoting colon cancer progression, as well as the neural crest-related birth defects caused by human mutations in DDX3 and downstream genes.<br></p><img alt="" src="https://testwww.bio.udel.edu/IMAGES%20BIOS/SHUO-WEI.JPG" style="BORDER:0px solid;" />Biological SciencesUniversity of Delawareduncanm@udel.edusts4s://publish.bio.udel.edu/attachmentUrl=https://publish.bio.udel.edu/Lists/Seminars/Attachments/1/Wei, Shuo_promotion seminar flyer.pdf
Integrated approach to gene discovery in ocular and craniofacial development and their associated birth defects4Integrated approach to gene discovery in ocular and craniofacial development and their associated birth defects318 Wolf Hall9/12/2019 6:00:00 PM9/12/2019 7:00:00 PMMelinda Duncan, Ph.D.Salil Lachke, Ph.D.<p>​The identification of genes linked to eye and craniofacial development and their associated defects presents a formidable challenge. In the recent past however, genome-level transcript profiling (transcriptomics) has become increasingly feasible due to technologies such as microarrays and RNA sequencing. Their application to interrogate specific eye and craniofacial tissues and cell types holds high promise to impact ocular and craniofacial gene discovery. However, global gene expression profiling has brought with it new challenges, such as parsing through the large amounts of data to prioritize select candidates, and testing their function in development by experimental validation. Toward these goals, the Lachke lab has developed strategies such as “in silicosubtraction” to construct a systems-based web-resource tool called iSyTE-integrated Systems Tool for Eye gene discovery (Kakranaet al. (2018) Nucleic Acids Research; Anand et al. (2018) Human Mutation; Anand et al. (2018) Human Genetics) -which has impacted the identification of new disease-linked genes (Siddamet al. (2018) PLoSGenetics; Krall et al. (2018) Human Genetics). Further, a second resource, SysFACE(Systems tool for craniofacial expression-based gene discovery) has impacted gene discovery in craniofacial defects (Cox et al. (2018) American Journal of Human Genetics; Butaliet al. (2019) Human Molecular Genetics). Here, I will discuss the impact of iSyTEand SysFACEon identification of new genes linked to lens biology/cataract and craniofacial defects, and how these efforts have allowed us to decipher the regulatory networks underlying the development of these tissues. Finally, I will outline the ongoing efforts for extending this approach to other tissues and organs.<br></p><img alt="" src="/content-sub-site/Documents/Seminars/2019/Lachke_Salil-2018-09.jpg" style="BORDER:0px solid;" />Biological SciencesUniversity of Delawareduncanm@udel.edusts4s://publish.bio.udel.edu/attachmentUrl=https://publish.bio.udel.edu/Lists/Seminars/Attachments/4/Lachke Salil_Promotion Seminar Flyer.pdf
L1CAM's influence on glioblastoma cell behavior and brain tumor formation8L1CAM's influence on glioblastoma cell behavior and brain tumor formation318 Wolf Hall9/16/2019 4:30:00 PM9/16/2019 5:30:00 PMPatricia DeLeonDeni Galileo, Ph.D.Biological SciencesUniversity of Delawarepdeleon@udel.edusts4s://publish.bio.udel.edu/attachmentUrl=https://publish.bio.udel.edu/Lists/Seminars/Attachments/8/Deni_Galileo_seminar.pdf
From Amoebae to Macrophages: Molecular Mechanisms of Legionella pneumophila Pathogenesis2From Amoebae to Macrophages: Molecular Mechanisms of Legionella pneumophila Pathogenesis318 Wolf Hall9/23/2019 8:00:00 PM9/23/2019 9:00:00 PMFidelma Boyd, Ph.D.Ramona Neunuebel, Ph.D.Biological SciencesUniversity of Delawarefboyd@udel.edusts4s://publish.bio.udel.edu/attachmentUrl=https://publish.bio.udel.edu/Lists/Seminars/Attachments/2/Neunuebel_seminar-flyer.pdf

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