Fowler began her faculty career in the Department of Anatomy and Cell Biology at Harvard Medical School in 1984 and moved to the Scripps Research Institute in 1987, where she was promoted to Professor in 2000. She relocated to UD in January 2019 to become Chair of the Department of Biological Sciences. Fowler's research focuses on actin cytoskeleton regulation of cellular architecture and biomechanics in tissue and organ function in development, physiology, and pathology. Fowler's Bibliography. In skeletal and cardiac muscle, she has taken a multi-scale approach to study muscle structure and function, using molecular genetics and imaging approaches from the nano- to centimeter scale to understand muscle structure and physiology (Figure 1). Her research showed that thin filament lengths in sarcomeres are regulated by actin dynamics at pointed but not barbed ends, and that precise regulation of thin filament length by proteins called tropomodulins (Tmods) controls length-tension relationships in muscle sarcomeres and determines the contractile force output of different skeletal muscles. Defects in thin filament length regulation by mutations in Tmod gene family members form the basis of several congenital cardiac, skeletal and smooth muscle myopathies. Fowler has published over 130 research papers, chapters, and reviews, has been cited over 8,000 times, and has an H-index of 57. She has mentored over 25 graduate students and postdoctoral fellows. Fowler was one of the founding members of the Scripps Graduate Program in 1989, served as Associate Dean from 2013-2019, and was nominated three times as Outstanding Mentor at Scripps.
Fowler has extensive experience with the NIH across multiple areas that will contribute to her leadership of the DCMR COBRE. She received her first NIH grant as PI in 1983 and has been continuously funded by NIH R01 grants as PI for 35 years. In addition to her long track record in investigator-initiated NIH research, Fowler has had extensive leadership experience in numerous NIH programs and review processes:
- NIH/NIAMS P30 Research Center, Associate Program Director and Imaging Core Co-Director (P30: San Diego Skeletal Muscle Research Center, PI: RL Lieber), 2011-2017
- NIH/NEI P30 Research Center, Imaging Core Co-Director (P30: Core Grant for Vision Research, PI: M Friedlander), 2001-2008
- Molecular and Cellular Hematology (MCH) Study Section, Member, 2009-2013
- NIH F32 postdoctoral fellowship and AREA grant Cell and Developmental Function Study Section, Member 1998-2001 and Chair 2001-2003
- NIH study section ad hoc member serving annually from 1991 to present (NEI, NBIB, NHLBI, NIDDK, F32s, various SEPs, NHLBI P30s)