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232Sonali Barwe, Ph.D. <p>Senior Research Scientist<br></p>(302) 651-6542 (302) 651-4827 sonali.barwe@nemours.org Rm 5207, E400, DuPont Experimental Station200 Powder Mill Road, Wilmington, DE 19803<ul> <li><strong>Ph.D.</strong> – Indian Institute of Science, India<br></li><li><strong>Postdoctoral</strong> – University of California, Los Angeles </li></ul><ul><li>Patient-derived xenograft models for preclinical testing of novel drugs with the goal of developing clinical trial concepts for pediatric leukemia </li><li>Deciphering the role of the bone marrow microenvironment in therapy resistance and identifying means to reverse it </li><li>Identifying cell surface receptors that mediate bone marrow microenvironment induced chemoprotection</li><li>Developing combinatorial epigenetic therapy for pediatric leukemia using patient-derived xenograft models</li><li>Understanding the role of ion transporters in cell adhesion<br></li></ul><ul><li><strong>Josh Faust</strong>, Research Assistant <br></li><li><strong>Kara Lehner</strong>, Graduate Student </li><li><strong>Kayla Hammond</strong>, Graduate Student </li></ul><ul><li>Quagliano A, Gopalakrishnapillai A, Kolb EA, <strong>Barwe SP</strong>. CD81 knockout promotes chemosensitivity and disrupts in vivo homing and engraftment in acute lymphoblastic leukemia. Blood Adv, Sep (4):4393-4405 (2020).<strong> </strong></li><li>Quagliano A, Gopalakrishnapillai A, <strong>Barwe SP</strong>. Understanding the mechanisms by which epigenetic modifiers avert therapy resistance in cancer. Front Oncol, Jun (10):992 (2020).<strong> </strong></li><li><strong>Barwe SP</strong>, Sidhu I, Kolb EA, Gopalakrishnapillai A. Modeling transient abnormal myelopoiesis using induced pluripotent stem cells and CRISPR/Cas9 technology. Mol Ther Methods Clin Dev, Sep (19):201-209 (2020).<strong> </strong></li><li>Sidhu I, <strong>Barwe SP</strong>, Gopalakrishnapillai A. The extracellular matrix: a key player in the pathogenesis of hematologic malignancies. Blood Reviews, Dec 8:100787 online ahead of print (2020).<br></li><li><strong>Barwe SP</strong>, Gopalakrishnapillai A, Mahajan N, Druley TE, Kolb EA, Crowgey EL. Strong concordance between RNA structural and single nucleotide variants identified via next generation sequencing techniques in primary pediatric leukemia and patient-derived xenograft samples. Genomics Inform, Mar (18):e6 (2020).<br></li><li>Kaeding AJ, <strong>Barwe SP</strong>, Gopalakrishnapillai A, Ries RE, Alonzo TA, Gerbing RB, Correnti C, Loken MR, Pardo L, Le Q, Tang T, Leonti A, Chou C, Triche T, Kolb EA, Meshinchi S, Tarlock K. Mesothelin is a novel cell surface disease marker and potential therapeutic target in acute myeloid leukemia. In press, Blood Adv.<br></li><li><strong>Barwe SP</strong>, Quagliano AJ, Gopalakrishnapillai A. Eviction from the sanctuary: development of targeted therapy against cell adhesion molecules in acute lymphoblastic leukemia. Sem Oncol, Apr 44(2): 101-112 (2017).<br></li><li>Balasubramaniam SL, Gopalakrishnapillai A, Petrelli NJ, <strong>Barwe SP</strong>. Knockdown of sodium-calcium exchanger 1 induces epithelial to mesenchymal transition in kidney epithelial cells. J Biol Chem, Jul (292): 11388-11399 (2017).<br></li><li>Gopalakrishnapillai A, Kolb EA, McCahan S, <strong>Barwe SP. </strong>Epigenetic drug combination induces remission in mouse xenograft models of pediatric acute myeloid leukemia. Leuk Res, Jul (58):91-97 (2017).<br></li><li>Quagliano A, Gopalakrishnapillai A, <strong>Barwe SP</strong>. Epigenetic drug combination overcomes osteoblast-induced chemoprotection in pediatric acute lymphoid leukemia. Leuk Res, May (56):36-43 (2017).<br></li><li>Gopalakrishnapillai A, Kolb EA, Dhanan P, Sri Bojja A, Mason RW, Corao D, <strong>Barwe SP</strong>. Generation of patient-derived pediatric leukemia models in NSG-B2m mice: Comparison with NOD/SCID mice. Front Oncol. 6:162 (2016).<br></li><li>Gopalakrishnapillai A, Kolb EA, Dhanan P, Mason RW, Napper A, <strong>Barwe SP</strong>. Disruption of annexin II/p11 interaction suppresses leukemia cell binding, homing and engraftment, and sensitizes leukemia cells to chemotherapy. PLOS One, October 10(10):e0140564 (2015).<br></li><li>Balasubramaniam SL, Gopalakrishnapillai A, <strong>Barwe SP</strong>. Ion-dependency of Na,K-ATPase mediated epithelial cell adhesion and migration. Am J Physiol Cell Physiol, September, 309(6):C437-441 (2015).<br></li><li>Balasubramaniam SL, Gopalakrishnapillai A, Gangadharan V, Duncan RL, <strong>Barwe SP</strong>. Sodium-calcium exchanger 1 regulates epithelial cell migration via calcium-dependent extracellular signal-regulated kinase signaling. J Biol Chem, May, 290(20): 12463-12473 (2015).<br></li><li><strong>Barwe SP</strong>, Skay A, McSpadden R, Inge L, Huynh T, Langhans, SA, Rajasekaran AK. Na,K-ATPase b-subunit cis homo-oligomerization is necessary for epithelial lumen formation in mammalian cells. J Cell Sci, December 125(23):p5711-5720 (2012).<br></li><li><strong>Barwe SP</strong>, Jordan MC, Skay A, Inge L, Rajasekaran SA, Wolle D, Johnson CL, Neco P, Fang K, Rozengurt N, Goldhaber JI, Roos KP, Rajasekaran AK. Dysfunction of ouabain-induced cardiac contractility in mice with heart-specific ablation of Na,K-ATPase beta1-subunit. J Mol Cell Cardiol, October 47 (4): p552-560 (2009).<br></li><li><strong>Barwe SP</strong>, Kim S, Rajasekaran SA, Bowie JU, Rajasekaran AK. Janus model of the Na,K-ATPase b-subunit transmembrane domain: Distinct faces mediate a/b subunit assembly and b-b homo-oligomerization. J Mol Biol, January 365 (3): p706-714 (2007).</li><li><strong>Barwe SP</strong><strong>*</strong>, Anilkumar G, Moon SY, Zheng Y, Whitelegge J, Rajasekaran SA, Rajasekaran AK. Novel role for Na,K-ATPase in PI3-kinase signaling and suppression of cell motility. Mol Biol Cell, March (16): p1082-1094 (2005).<br></li></ul><img alt="" src="/Images%20Bios/Barwe%20UD%20Webpage.jpg" style="BORDER:0px solid;" />

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