| 290 | Justin Parreno, Ph.D. | <p>​​Assistant Professor<br></p> | (302) 831-3776 | | jparreno@udel.edu | 329 Wolf Hall | 341 Wolf Hall | 105 The Grn, 341 Wolf Hall, Newark, DE 19716 | <p></p><ul><li>Postdoctoral ; Scripps Research (La Jolla, CA) and the University of Delaware (Newark, DE); Natural Sciences and Engineering Research Council of Canada Post-doctoral Fellow​</li><li>Ph.D. ; University of Toronto (Toronto, Ontario, Canada) ; Natural Sciences and Engineering Research Council of Canada Alexander Graham Bell Scholar</li><li>M.Sc. - University of Calgary (Calgary, Alberta, Canada)</li><li>B.Sc. - University of Calgary (Calgary, Alberta, Canada)<br></li></ul><p></p> | | <p>​We are interested in delineating the involvement of actin network reorganization in regulating articular cartilage and ocular lens biology and disease. Our vision is to develop novel actin-based therapeutics against disease. <br></p> | <p>See <a href="https://www.parrenolab.com/">Parrenolab.com</a> to see ongoing projects and more lab information.<br></p> | <p>​We are looking to recruit motivated personnel and trainees. Please contact jparreno@udel.edu for more information.<br></p> | <p></p><p>​​<strong>Parreno
J</strong>, Amadeo M, Kwon E, and Fowler VM. Tropomyosin
3.1 Regulates Epithelial-to-Mesenchymal Transition in Lens Epithelial Cells.
Invest Ophthalmol Vis Sci. (Accepted - In Press)</p><p>Delve
E, Co V, Regmi J, <strong>Parreno J</strong>, Schmidt T, and Kandel RA. CDC42 and actin
polymerization status regulates YAP/TAZ in superficial zone chondrocytes.
eCells & Materials. Eur Cell Material. 2020 Jan 9;39:48-64</p><p>Cheng
C, <strong>Parreno J</strong>, Nowak RB, Bisas SK, Lo WK, Wang K, Piersionek B, and Fowler
VM. Age-Related Changes in Lens Biomechanics, Cell Morphology, Refractive
Index, and Transparency. Aging. 2019 Dec 16;11(24):12497-12531</p><p>Bianchi
V, Lee A, Anderson J, <strong>Parreno J</strong>, Theodoropoulus J, Backstein D, Kandel
RA. Re-differentiated Chondrocytes in Fibrin Gel for Repair of Articular
Cartilage Lesions. The American Journal of Sports Medicine. 2019 Aug;47(10):2348-2359. </p><p>Chan
B, <strong>Parreno J</strong>, Wang Y, Glogauer M, Kandel RA. The Role of Adseverin in
Regulating Chondrocyte Phenotype and Function. J Tissue Eng Regen Med. 2019
Aug;13(8):1438-1452.</p><p><strong>Parreno
J</strong> and Fowler V. Multifunctional role of
tropomodulin-3 in regulating actin dynamics. Biophysical Reviews. 2018
Dec;10(6):1605-1615</p><p><strong>Parreno
J</strong>, Cheng C, Novak R, Fowler V. The effects of
mechanical strain on mouse eye lens capsule and cellular microstructure.
Molecular Biology of the Cell. 2018 Aug 8;29(16):1963-1974Â </p><p>Delve
E, <strong>Parreno J</strong>, Co V, Wu P, Chong J, Di Scipio M, Kandel RA. CDC42
regulates the Expression of Superficial Zone Molecules in part through the
Actin Cytoskeleton and Myocardin-Related Transcription Factor-A. Journal of
Orthopaedic Research. 2018 Sep;36(9):2421-2430</p><p><strong>Parreno
J</strong>, Bianchi V, Sermer C, Regmi S, Backstein D,
Schmidt T, Kandel RA. Adherent agarose mold cultures: an in vitro platform for
multi-factorial assessment of passaged chondrocyte redifferentiation. Journal
of Orthopaedic Research. 2018 Sep;36(9):2392-2405</p><p><strong>Parreno
J</strong>, Nabavi Niaki M, Andrejevic K, Jiang A, Wu PH,
Kandel RA. Interplay between cytoskeletal polymerization and the chondrogenic
phenotype in chondrocytes expanded in monolayer. Journal of Anatomy. 2017 Feb
230(2):234-248</p><p><strong>Parreno
J</strong>, Raju S, Nabavi Niaki M, Andrejevic K, Jiang A,
Delve E, Kandel RA. MRTF-A signaling regulates the acquisition of the contractile
phenotype in dedifferentiated chondrocytes. Matrix Biol. 2017 Oct;62:3-14.</p><p><strong>Parreno
J</strong>, Delve E, Andrejevic K, Paez-Parent S, Wu PH,
Kandel RA. Efficient, low-cost nucleofection of chondrocytes. Cartilage. 2016
Jan. 7(1) 82–91.</p><p>Taylor
DW, Ahmed N, <strong>Parreno J</strong>, Lunstrum GP, Gross AE, Diamandis EP, Kandel RA.
Collagen type XII and versican are present in the early stages of cartilage
tissue formation by both redifferentating passaged and primary chondrocytes.
Tissue Eng. Part A. 2015 Feb;21(3-4):683-93</p><p><strong>Parreno
J</strong>, Raju S, Niaki MN, Andrejevic K, Jiang A, Delve
E, Kandel R. Expression of type I collagen and tenascin C is regulated by actin
polymerization through MRTF in dedifferentiated chondrocytes. FEBS Letters.
2014 Oct 16;588(20):3677-84. </p><p><strong>Parreno
J</strong>, Hart DA. Molecular and mechano-biology of
collagen gel contraction mediated by human MG-63 cells: involvement of specific
intracellular signaling pathways and the cytoskeleton. Biochem Cell Biol. 2009
Dec;87(6):895-904. </p><p><strong>Parreno
J</strong>, Buckley-Herd G, de-Hemptinne I, Hart DA.
Osteoblastic MG-63 cell differentiation, contraction, and mRNA expression in
stress-relaxed 3D collagen I gels. Mol Cell Biochem. 2008 Oct;317(1-2):21-32.</p><p>de
Hemptinne I, Gallant-Behm CL, Noack CL, <strong>Parreno J</strong>, Hart DA. Dermal
fibroblasts from red Duroc and Yorkshire pigs exhibit intrinsic differences in
the contraction of collagen gels. Wound Repair Regen. 2008
Jan-Feb;16(1):132-42.</p><p></p> | | | <img alt="Dr. Justin Parreno" src="/content-sub-site/PublishingImages/people/jparreno/jparreno.jpg" style="BORDER:0px solid;" /> | |
