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301Joohyun (Jason) Lim, Ph.D.<p>​​​​​​​​​​​Assistant​ Professor​<br></p>(302) 831-6685limj@udel.edu244 Wolf Hall007/008 Wolf HallDepartment of Biological Sciences, Wolf Hall, Newark, DE 19716 <p><strong>B.S.</strong>, Pennsylvania State University, University Park, PA<br><strong>M.S.</strong>, University of California, Irvine, CA<br><strong>Ph.D.</strong>, Washington University in St. Louis, MO<br><strong>Postdoc</strong>, Baylor College of Medicine, Houston, TX​<br></p><p>BISC415/615 - Developmental Biology (Spring)​<br></p><p>Our research is focused on understanding how individual components in joint tissues, including the tendon, bone, and cartilage, are formed and maintained throughout life. Cells residing in these adjacent yet distinct tissues are regulated by unique mechanisms (<a href="https://pubmed.ncbi.nlm.nih.gov/26657771/">Lim et al. 2016</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/29215029/">Lim et al. 2017</a>). Furthermore, abnormalities in these musculoskeletal resident cell populations can contribute to disease such as osteoarthritis (OA) or temporomandibular joint OA (TMJ-OA) which affects over 15 million individuals in the United States. </p><p>Our overarching goal is (1) to investigate mechanisms of cell differentiation and function that are essential for the development and maintenance of unique cell types that reside in the TMJ, and (2) to determine how alterations in these mechanisms contribute to TMJ-OA and temporomandibular disorders (TMDs). We will address these questions by using multi-disciplinary approaches, including state-of-the-art imaging techniques, single cell and spatial transcriptomics, mouse genetic tools, and 3D in vitro culture models.<br></p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/myncbi/joohyun.lim.1/bibliography/public/"><strong>Full list of publications</strong></a></p><p><strong>Lim J</strong>, Lietman C, Grol MW, Castellon A, Dawson B, Adeyeye M, Rai J, Weis M, Keene DR, Schweitzer R, Park D, Eyre DR, Krakow D, Lee BH. Localized chondro-ossification underlies joint dysfunction and motor deficits in the Fkbp10 mouse model of osteogenesis imperfecta. Proc Natl Acad Sci U S A. 2021 Jun 22;118(25):e2100690118. PMID: 34161280.</p><p>Grol MW, Haelterman NA, <strong>Lim J</strong>, Munivez EM, Archer M, Hudson DM, Tufa SF, Keene DR, Lei K, Park D, Kuzawa CD, Ambrose CG, Eyre DR, Lee BH. Tendon and motor phenotypes in the Crtap-/- mouse model of recessive osteogenesis imperfecta. eLife. 2021 May 26;10:e63488. PMID: 34036937.</p><p><strong>Lim J</strong>, Munivez E, Jiang MM, Song IW, Gannon F, Keene DR, Schweitzer R, Lee BH, Joeng KS. mTORC1 Signaling is a Critical Regulator of Postnatal Tendon Development. Sci Rep. 2017 Dec 7;7(1):17175. PMID: 29215029.</p><p>Joeng KS, Lee YC, <strong>Lim J</strong>, Chen Y, Jiang MM, Munivez E, Ambrose C, Lee BH. Osteocyte-specific WNT1 regulates osteoblast function during bone homeostasis. J Clin Invest. 2017 Jun 30;127(7):2678-2688. PMID: 28628032.</p><p><strong>Lim J</strong>, Shi Y, Karner CM, Lee SY, Lee WC, He G, Long F. Dual function of Bmpr1a signaling in restraining preosteoblast proliferation and stimulating osteoblast activity in mouse. Development. 2016 Jan 15;143(2):339-47. PMID: 26657771.</p><p>Regan JN, <strong>Lim J</strong>, Shi Y, Joeng KS, Arbeit JM, Shohet RV, Long F. Up-regulation of glycolytic metabolism is required for HIF1α-driven bone formation. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8673-8. PMID: 24912186.<br></p><p>​</p><p><br></p><p><a href="https://limlab.udel.edu/" target="_blank" rel="noopener noreferrer" style="box-sizing:border-box;background-color:#ffffff;color:#306090;font-family:"segoe ui", "open sans", arial, sans-serif;font-size:14px;">https://limlab.udel.edu/</a>​<br></p><img alt="Jason Lim" src="/Images%20Bios/lim-joohyun.jpeg" style="BORDER:0px solid;" />

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