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172Salil A. Lachke, Ph.D. <p>​​Associate Chair<br></p> <p>Professor of Biological Sciences<br></p><p>Alumni Distinguished Early Career Professor of Biology<br></p> <p>Gerard J. Mangone Scholar</p> <p>Pew Scholar in the Biomedical Sciences </p>(302) 831-3040 (302) 831-2281 salil@udel.edu 236 Wolf Hall 351 Wolf Hall Department of Biological Sciences Wolf Hall University of Delaware Newark, DE 19716 <ul> <li><span style="font-family:arial, helvetica, sans-serif;"><strong>B.Sc.</strong> - The University of Pune, India, 1994</span></li><li><span style="font-family:arial, helvetica, sans-serif;"><strong>M.Sc.</strong> - The University of Pune, India, 1996</span></li><li><span style="font-family:arial, helvetica, sans-serif;"><strong>Ph.D.</strong> - The University of Iowa, Iowa City, 2003</span></li><li><span style="font-family:arial, helvetica, sans-serif;"><strong>Postdoc</strong> - Harvard Medical School and Brigham and Women's Hospital, 2003-2010</span></li><li><span style="font-family:arial, helvetica, sans-serif;"><strong>Instructor in Medicine</strong> - Harvard Medical School, 2011</span></li></ul> <p>Dr. Lachke teaches Molecular Biology of the Cell BISC401 (Honors), gives lectures in Biochemical Genetics BISC654 and serves as an instructor for undergraduate research taken for credit in BISC468.  He a​lso serves as research advisor for undergraduate Senior Thesis, graduate Masters Thesis, and Doctoral Dissertation.​<br></p><p></p><p>The Lachke laboratory uses interdisciplinary approaches for the identification and functional elucidation of genes involved in organ development and disease. We have developed a bioinformatics approach termed "<a href="https://research.bioinformatics.udel.edu/iSyTE/ppi/">iSyTE</a>" (integrated Systems Tool for Eye gene discovery, <a href="https://pubmed.ncbi.nlm.nih.gov/29036527/">Kakrana 2018 Nucleic Acids Research</a>) and have successfully used it to identify novel cataract genes and predict several other uncharacterized genes with function in lens development.  Our goal is to characterize these genes using biochemical, molecular, cell biological, and omics-level approaches.  As an important step toward this goal, we have used iSyTE to uncover the role of several new regulators, including CAPRIN2, CELF1, ELAVL1, RBM24, and TDRD7 (post-transcriptional regulatory RNA-binding proteins) and ELL2, MAFG and MAFK (transcription regulators) in lens development and cataractogenesis (<a href="https://pubmed.ncbi.nlm.nih.gov/21436445/">Lachke 2011 Science</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/26177727/">Dash 2015 Developmental Dynamics</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/29565969/">Siddam 2018 PLoS Genetics</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/31814023/">Dash 2020 Human Molecular Genetics</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/32420594/">Barnum 2020 Human Molecular Genetics</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/34127677/">Choquet 2021 Nature Communications</a>).  Our long-term mission is to define the gene regulatory networks (GRNs) that underlie organogenesis, in order to devise new therapies.  In addition to its clinical significance, we anticipate that insights gained from this research can unveil fundamental regulatory principles underlying cellular differentiation and organogenesis.</p><p>Dr. Lachke is an internationally renowned leader in eye development and cataract research having been recognized as Fight For Sight Young Investigator (2012), <a href="https://www1.udel.edu/udaily/2013/jun/infants-cataracts-061313.html">Knights Templar Young Investigator</a> (2013), <a href="https://www1.udel.edu/udaily/2013/apr/alcon-ophthalmology-040213.html">Alcon Young Investigator</a> (2013), <a href="http://www.nasonline.org/programs/kavli-frontiers-of-science/frontiers-alumni/alumni-directory/salil-lachke.html">Kavli Fellow</a> (2013), <a href="https://www.udel.edu/udaily/2016/october/mangone-young-scholars-award/">Gerard J. Mangone Young Scholar</a> from the Francis Alison Society (2016) and <a href="https://cataractresearch.org/awards/">Cataract Research Award</a> recipient from the National Foundation for Eye Research (2020).  Significantly, Dr. Lachke was also named a Pew Scholar in The Biomedical Sciences by The Pew Charitable Trusts – a distinct honor awarded to<em> “</em><a href="https://www.pewtrusts.org/en/about/news-room/press-releases-and-statements/0001/01/01/22-of-americas-most-promising-scientists-selected-as-pew-biomedical-scholars"><em>22 of America's Most Promising Scientists</em></a><em>"</em> (2012).  In addition to research, Dr. Lachke has been recognized for his role as a teacher, mentor and an advisor, having received from the University of Delaware, the <a href="https://www1.udel.edu/udaily/2014/may/senior-thesis-mentor-050714.html">Senior Thesis Mentor Award</a> (2014), <a href="https://www.udel.edu/udaily/2019/may/faculty-awards-excellence-in-teaching-advising-mentoring/">Excellence in Undergraduate Advising and Mentoring Award</a> (2019) and <a href="https://www.bio.udel.edu/people/faculty-spotlight1/faculty-spotlight/may-2020-salil-lachke">Excellence in Teaching Award</a> (2020).  Dr. Lachke holds an endowed professorship at UD, named as the <a href="https://provost.udel.edu/academics/named-professors/named-professors-cas/">Alumni Distinguished Early Career Professor of Biology</a>.</p><p>Dr. Lachke's trainees have found excellent placements in various capacities in academia and industry. For example, they have found opportunities in academic institutions such as Baylor College of Medicine, Cambridge University, Harvard Medical School, Johns Hopkins University, Northwestern University, Sidney Kimmel Medical College at Thomas Jefferson University, Stowers Institute for Medical Research, University of Delaware, University of Pennsylvania, as well as in non-academic institutions such as Agilent Biotech, AstraZeneca, Capricor, DuPont, SeraCare LifeSciences, Suvoda, U.S. Department of Defense , U.S. Food and Drug Administration and WuXi AppTech.</p><p>Watch a video summary of Dr. Lachke's research <a href="https://www.youtube.com/watch?v=_fWBlzbFI-Y">here</a>.<br>Watch Dr. Lachke's lecture on the 2012 Nobel prize winning work of Dr. John Gurdon and Dr. Shinya Yamanaka <a href="https://www.youtube.com/watch?v=Q1m8QGStWQc">here</a>.<br>If you are an ARVO member, watch Dr. Lachke's presentation in the 2015 ARVO minisymposium "<em>Integrated genomic networks in eye development and pathogenesis</em>" <a href="http://arvoconnect.arvo.org/arvoeducation/communities/resources/viewdocument?DocumentKey=4bf3ace5-37fa-4ea3-ab8f-f78f019bec75">here</a>.<br>Watch Dr. Lachke's seminar in the Innovative Discoveries Series, at the Delaware Clinical & Translational Research ACCEL Program and the Christiana Care Value Institute <a href="https://www.de-ctr.org/node/1565">here</a>.<br>Read Dr. Francis Collins' comments on Dr. Lachke's research in the <a href="https://directorsblog.nih.gov/2018/05/17/snapshots-of-life-lens-crafting/">NIH Director's Blog</a></p><p>For more information, visit <a href="https://sites.udel.edu/lachke-lab/">Dr. Lachke's laboratory webpage</a>.<br><br></p><p></p><p><strong>​Lachke, S.A.</strong>, Alkuraya, F.S., Kneeland, S., Ohn, T., Aboukhalil, A., Howell, G., Saadi, I., Cavallesco, R., Yingzi, Y., Tsai, A.C-H, Nair, S.K., Cosma, M.I., Smith, R.S., Hodges, E., AlFadhli, S.M., Al-Hajeri, A., Shamseddin, H., Behbehani A., Hannon, G., Bulyk, M.L., Drack, A.V., Anderson, P.J., John, S.W., Maas, R.L. (2011) Mutations in the RNA granule component TDRD7 cause cataract and glaucoma.</p><em>Science</em>, 331:1571-1576. PMCID: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279122/">PMC3279122</a><br><strong>*Highlighted in Science, 2011:331, 1523-24</strong><br><strong>*Highlighted in Cell, 2011:145, 331</strong><br><strong>*Highlighted in Nature Genetics, 2011:43(5), 403</strong><br><strong>*Highlighted in </strong><a href="https://www.nih.gov/news-events/nih-research-matters/eye-development-error-causes-cataracts-glaucoma"><strong>NIH Research Matters</strong></a><br><br>Agrawal, S.A., Anand, D., Siddam, A.D., Kakrana, A., Dash, S., Schieblin, D.A., Dang, C.A., Terrell, A.M., Waters, S.M., Singh, A., Motohashi, H., <strong>Lachke, S.A. </strong>(2015)<strong> </strong>Compound mouse mutants of bZIP transcription factors Mafg and Mafk reveal a regulatory network of lens fiber cell genes in cataractogenesis.<br><em>Human Genetics</em>, 134:717-735 PMCID: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486474/">PMC4486474</a><br><strong>*Among Top Accessed Articles,</strong> >7800 accesses; in the <a href="https://springeropen.altmetric.com/details/4025701#score">top 10%</a> of all research articles of a similar age tracked by Altmetric (<em>n</em>=265,378)<div><br></div><div>Anand, D., <strong>Lachke, S.A.</strong> (2017) Systems biology of lens development: a paradigm for disease gene discovery in the eye.<br><em>Experimental Eye Research</em>, 156:22-33 PMCID: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026553/">PMC5026553</a><br><strong>*Among the Top 25 Most Downloaded </strong><strong><em>Experimental Eye Research</em></strong><strong> Articles </strong>(March – July 2016)</div><div><br></div><div>Siddam, A.D., Gautier-Courteille, C., Perez-Campos, L., Anand, D., Kakrana, A., Dang, C.A., Legagneux, V., Mereau, A., Viet, J., Gross, J.M., Paillard, L., <strong>Lachke, S.A.</strong> (2018) The RNA-binding protein Celf1 post-transcriptionally regulates p27<sup>Kip1</sup> and Dnase2b to control fiber cell nuclear degradation in lens development.<br><em>PLoS Genetics</em>, 14(3):e1007278 PMCID: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889275/">PMC5889275</a><br><strong>*Commented on by Nobel Laureate Craig Mello</strong><br><strong>*Featured on </strong><strong><em>PLoS Genetics</em></strong><strong> Webpage</strong></div><div><br></div><div><strong></strong>Kakrana, A., Yang, A., Anand, D., Djordjevic, D., Ramachandruni, S.D., Singh, A., Huang, H., Ho, J.W.K., <strong>Lachke, S.A.</strong> (2018) iSyTE 2.0: a developmental expression-based database for eye gene discovery.<br><em>Nucleic Acids Research</em>, 46(D1):D875-D885 PMCID: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753381/">PMC5753381</a><br><strong>*Commented on by Dr. Francis Collins in NIH Director's Blog</strong></div><div><br></div><div><strong></strong>Anand, D., Agrawal, S.A., Slavotinek, A., <strong>Lachke, S.A.</strong> (2018) Mutation update of transcription factor genes <em>HSF4</em>, <em>FOXE3</em>, <em>MAF</em> and <em>PITX3</em> causing cataracts and other developmental ocular defects.<br><em>Human Mutation</em>, 39:471-494 PMCID: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839989/">PMC5839989</a><br><strong>*Article Featured on Cover</strong><br><strong>*Selected in </strong><strong><em>Human Mutation</em></strong><strong> “Editor's Choice Articles in 2018"</strong></div><div><br></div><div><strong></strong>Dash, S., Brastrom, M.K., Patel, S.D., Scott, A.C., Slusarski, D.C., <strong>Lachke, S.A.</strong> (2020) The master transcription factor SOX2, mutated in microphthalmia/anophthalmia, is post-transcriptionally regulated by the conserved RNA-binding protein RBM24 in vertebrate eye development.<br><em>Human Molecular Genetics</em>, 29:591-604, PMCID: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068108/">PMC7068108</a><br><strong>*Article Featured on Cover</strong>​<br><p></p><p>Barnum, C.E., Al Saai, S., Patel, S.D., Cheng, C., Anand, D., Xu, X., Dash, S., Siddam, A.D., Glazewski, L., Paglione, E., Polson, S., Chuma, S., Mason R.W., Wei, S., Batish, M., Fowler, V.M., <strong>Lachke, S.A. </strong>(2020)<strong> </strong>The Tudor-domain family protein TDRD7, mutated in congenital cataract, controls the heat shock protein HSPB1 and lens fiber cell morphology.<br><em>Human Molecular Genetics</em>, 29:2076-2097 PMCID: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390939/">PMC7390939</a><br><strong>*Article Featured on Cover</strong><br><strong>*Among Top 5 Most Read HMG Articles, </strong>>15,000 views</p><p>Choquet, H., Melles, R.B., Anand, D., Yin, J., Cuellar-Partida, G., Wang, W., 23andMe Research Team, Hoffman, T.J., Nair, K.S., Hysi, P.G., <strong>Lachke, S.A.</strong><strong>*</strong>, Jorgenson, E.<strong>*</strong> (2021) A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects.<br><em>Nature Communications</em>, 12:3595 PMCID: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203611/">PMC8203611</a> <strong>*</strong>These authors jointly supervised this work<br><strong>*Highlighted in 23andMe Blog</strong><br><strong>*Highlighted in Kaiser Permanente Spotlight</strong><br></p><p><strong>Lachke, S.A.</strong><strong> </strong>(2022) RNA-binding proteins and post-transcriptional regulation associated with lens biology and cataract: mediating spatiotemporal control of key factors involved in the cell cycle, transcription, cytoskeleton and transparency.<br><em>Experimental Eye Research</em>, 214:108889 PMCID: <a href="https://pubmed.ncbi.nlm.nih.gov/34906599/">PMC8792301</a></p><p><span style="text-decoration:underline;"><strong>Complete List of Publications</strong></span><br><a href="https://www.ncbi.nlm.nih.gov/myncbi/1LAWHa1aETwMOf/bibliography/public/">https://www.ncbi.nlm.nih.gov/myncbi/1LAWHa1aETwMOf/bibliography/public/</a>​<br></p><p></p></div><img alt="" src="/content-sub-site/PublishingImages/people/salil/Salil%20Lachke%20Nov%202019.jpg" style="BORDER:0px solid;" />

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