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175Shuo Wei, Ph.D. <p>​Associate Professor<br></p><p>Executive editor, <em>J. Cell. Physiol.</em> (Wiley)<br></p><p>Editorial board member, <em>Sci. Rep. </em>(NPG)<br></p>(302) 831-1146 swei@udel.edu 235 Wolf Hall 259 and 262 Wolf Hall <ul> <li><p>B.S. in Biology, University of Science and Technology of China </p></li><li><p>Ph.D. in Biochemistry and Molecular Biology, University of Miami<br></p></li><li><p>Postdoc in Cell and Developmental Biology, University of Virginia </p></li></ul><p><strong>Fall:</strong> BISC401/609 <em>Molecular Biology of the Cell</em></p> <p><strong>Spring:</strong> BISC467/667 <em>Current Topics in Development and Cancer</em></p><p>The Wei lab is interested in the regulation of cell signaling and tissue homeostasis by metalloproteinases and other proteins in development and disease.</p><p><strong>Project 1. The mechanisms of neural crest development and related birth defects.</strong> The neural crest cells are multipotent stem cells that give rise to craniofacial structures, cardiac tissues, pigment cells, the peripheral nervous system, and many other derivatives. Aberrant neural crest development can lead to some of the most common birth defects in humans, such as craniofacial disorders and congenital heart diseases. Using the Western clawed frog <em>Xenopus tropicalis</em> as a model, we are investigating the roles of several genes and signaling pathways, including the AKT and canonical Wnt pathways, in inducing neural crest formation under normal and pathological conditions. In particular, we are interested in modeling human neural crest birth defects caused by genetic mutations.</p><p><strong>Project 2. Function and regulation of canonical Wnt signaling.</strong> The canonical Wnt pathway plays important roles in development and disease, including neural crest induction, carcinogenesis and tumor progression. Both the inputs and outputs of Wnt signaling are regulated by many genes through various mechanisms, and perturbation of any of these regulatory mechanisms may lead to diseases. A major focus of our research is on identifying novel upstream regulators and downstream effectors of Wnt signaling and understanding their functions in normal and pathological processes.</p><p><strong>Project 3. The biochemistry and cell biology of extracellular metalloproteinases.</strong> Extracellular metalloproteinases, such as disintegrin metalloproteinases (ADAMs) and matrix metalloproteinases (MMPs), are key regulators of cell signaling and tissue homeostasis. Abnormal ADAM/MMP activities are often associated with pathological processes such as tumor progression, cartilage degradation (as in arthritis), and neurodegenerative diseases. We are interested in understanding how the expression, maturation and activities of these metalloproteinases are controlled, as well as identifying novel ADAM/MMP substrates using both candidate and nonbiased (proteomics) approaches. Finally, we are also collaborating with other labs at UD to identify new synthetic and natural ADAM/MMP inhibitors for potential therapeutic purposes.<br></p><p></p><ul><li><p><strong>Yu Shi</strong> - Postdoctoal research associate (Ph.D., Kunming Institute of Zoology, Chinese Academy of Sciences, China)<br></p></li><li><p><strong>Ryan Kempski</strong> - Lab technician (B.S., University of Delaware)<br></p></li><li><p><strong>Pathirennehelage (“Chamath”) Chandrasekera</strong> – Ph.D. student (B.S., Baylor University)<br></p></li><li><p><strong>Congyu Lu</strong> – Ph..D student, Bioinformatics and Computational Biology Program (M.S., University of Delaware)<br></p></li><li><p><strong>Xiaolu Xu</strong> - Ph.D. student (B.S., Shandong University, China)<br></p></li><li><p><strong>Brett Graver</strong> - Ph.D. rotation student<br></p></li><li><p><strong>Richard Roberts</strong> - Ph.D. rotation student<br></p></li><li><p><strong>Ally Szuter</strong> - Undergrad student<br></p></li><li><p><strong>Gabriella Esquivel</strong> - Undergrad student<br></p></li></ul><p></p><p>Congratulations to <strong>Effie</strong> and <strong>Andrew</strong> for successfully defending their theses! What an achievement during this tough time!<br></p><p> </p><p></p><ul><span style="font-size:13px;"><li><p><span style="font-size:15px;">Chan​​drasekera, P., Perfetto, M., Zhuo M., Bahudhanapati, H., Chen, W.C., Kulkarni, P., Christian, L., Lu, C., Liu, J., Yien, Y.Y.,​ Li, J., Yu, C., and <strong>Wei, S.</strong> AD​AM9 cleaves ephrin-Bs and differentially regulates Wnt and mTOR s​ignaling downstream of Akt in colorectal cancer cells. <em style="text-decoration:underline;">J. Biol. Chem.</em>, in revision.​<br></span></p></li><li><p><span style="font-size:15px;">Wang, J., Lu, C., and <strong>Wei, S.</strong> Whole-genome sequencing identifies I-SceI-mediated transgene integration sites in Xenopus tropicalis snai2:eGFP line. <em style="text-decoration:underline;">G3</em>, in revision.<br></span></p></li><li><p><span style="font-size:15px;">Perfetto, M., Xu, X., Lu, C., Shi, Y., Yousaf, N., Li, J., Yien, Y.Y., and </span><strong style="font-size:15px;">Wei, S.</strong><span style="font-size:15px;"> (2021) </span><a href="https://pubmed.ncbi.nlm.nih.gov/33318149/"><span style="font-size:15px;">The RNA helicase DDX3 induces neural crest by promoting AKT activity.</span></a><span style="font-size:15px;"> </span><em style="text-decoration:underline;font-size:15px;">Development</em><span style="font-size:15px;"> 148, dev184341.</span><br style="font-size:15px;"></p></li><li><p><span style="font-size:15px;">Halakos, E.G., Connell, A., Glazewski, L., </span><strong style="font-size:15px;">Wei, S.</strong><span style="font-size:15px;">*, and Mason, R.W.* (2021) </span><a href="https://pubmed.ncbi.nlm.nih.gov/33278663/"><span style="font-size:15px;">Bottom up proteomics identifies neuronal differentiation pathway networks activated by cathepsin inhibition treatment in neuroblastoma cells that are enhanced by concurrent 13-cis retinoic acid treatment.</span></a><span style="font-size:15px;"> </span><span style="text-decoration:underline;font-size:15px;"><em>J. Proteomics</em></span><span style="font-size:15px;"> 232, 104068. * Co-senior authors.</span><br style="font-size:15px;"></p></li><li><p><span style="font-size:15px;">Perfetto, M., Kirkham, S.G., Ayers, M.C., </span><strong style="font-size:15px;">Wei, S.</strong><span style="font-size:15px;">, and Gallagher, J.E.G. (2021) </span><a href="https://www.sciencedirect.com/science/article/pii/S2214750020304510"><span style="font-size:15px;">4-Methylcyclohexane methanol (MCHM) affects viability, development, and movement of Xenopus embryos.</span></a><span style="font-size:15px;"> </span><em style="text-decoration:underline;font-size:15px;">Toxicol. Rep.</em><span style="font-size:15px;"> 8, 38-43.</span><br style="font-size:15px;"></p></li><li><p><span style="font-size:15px;">Barnum, C.E., Al Saa, S., Patel, S.D., Cheng, C., Anand, D., Xu, X., Dash, S., Siddam, A.D., Glazewski, L., Paglione, E., Polson, S., Chuma, S., Mason, R.W., </span><strong style="font-size:15px;">Wei, S.</strong><span style="font-size:15px;">, Batish, M., Fowler, V.M., and Lachke, S.A. (2020) </span><a href="https://pubmed.ncbi.nlm.nih.gov/32420594/"><span style="font-size:15px;">The Tudor-domain protein TDRD7, mutated in congenital cataract, controls the heat shock protein HSPB1 (HSP27) and lens fiber cell morphology.</span></a><span style="font-size:15px;"> </span><em style="text-decoration:underline;font-size:15px;">Hum. Mol. Genet.</em><span style="font-size:15px;"> 29, 2076-2097.</span><br style="font-size:15px;"></p></li><li><p><span style="font-size:15px;">Pei, S., Parthasarathy, S., Parajuli, A., Martinez, J., Lv, M., Jiang, S., Wu, D., </span><strong style="font-size:15px;">Wei, S.</strong><span style="font-size:15px;">, Lu, X.L., Farach-Carson, M.C., Kirn-Safran, C.B., and Wang, L. (2020) </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/31715337"><span style="font-size:15px;">Perlecan/Hspg2 deficiency impairs bone's calcium signaling and associated transcriptome in response to mechanical loading.</span></a><span style="font-size:15px;"> </span><em style="text-decoration:underline;font-size:15px;">Bone</em><span style="font-size:15px;"> 131, 115078.</span><br style="font-size:15px;"></p></li><li><p><span style="font-size:15px;">Halakos, E.G., Connell, A., Glazewski, L., </span><strong style="font-size:15px;">Wei, S.</strong><span style="font-size:15px;">*, and Mason, R.W.* (2019) </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/31472280"><span style="font-size:15px;">Bottom up proteomics reveals novel differentiation proteins in neuroblastoma cells treated with 13-cis retinoic acid.</span></a><span style="font-size:15px;"> </span><em style="text-decoration:underline;font-size:15px;">J. Proteomics</em><span style="font-size:15px;"> 209, 103491. * Co-senior authors.</span><br style="font-size:15px;"></p></li><li><p><span style="font-size:15px;">Li, J.†, Perfetto, M.†, Materna, C., Li, R., Tran, H.T., Vleminckx, K., Duncan, M.K., and </span><strong style="font-size:15px;">Wei, S.</strong><span style="font-size:15px;"> (2019) </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/31371771"><span style="font-size:15px;">A new transgenic reporter line reveals Wnt-dependent Snai2 re-expression and cranial neural crest differentiation in Xenopus.</span></a><span style="font-size:15px;"> </span><em style="text-decoration:underline;font-size:15px;">Sci. Rep.</em><span style="font-size:15px;"> 9, 11191. † Equal contributors.</span><br style="font-size:15px;"></p></li><li><p><span style="font-size:15px;">Li, J.†, Perfetto, M.†, Neuner, R., Bahudhanapati, H., Christian, L., Mathavan, K., Bridges, L.C., Alfandari, D., and </span><strong style="font-size:15px;">Wei, S.</strong><span style="font-size:15px;"> (2018) </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29540504/"><span style="font-size:15px;">Xenopus ADAM19 regulates Wnt signaling and neural crest specification by stabilizing ADAM13.</span></a><span style="font-size:15px;"> </span><em style="text-decoration:underline;font-size:15px;">Development</em><span style="font-size:15px;"> 145, dev158154. † Equal contributors.</span><br style="font-size:15px;"></p></li><li><p><span style="font-size:15px;">Wang, J., Koganti, P., Yao, J., </span><strong style="font-size:15px;">Wei, S.</strong><span style="font-size:15px;">, and Cleveland, B. (2017) </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28924252/"><span style="font-size:15px;">Comprehensive analysis of lncRNAs and mRNAs in skeletal muscle of rainbow trout (Oncorhynchus mykiss) exposed to estradiol.</span></a><span style="font-size:15px;"> </span><em style="text-decoration:underline;font-size:15px;">Sci. Rep.</em><span style="font-size:15px;"> 7, 11780.</span><br style="font-size:15px;"></p></li><li><p><span style="font-size:15px;">Li, J., Qu, J., Shi, Y., Perfetto, M., Ping, Z., Christian, L., Niu, H., Mei, S., Zhang, Q, Yang, X. and </span><strong style="font-size:15px;">Wei, S.</strong><span style="font-size:15px;"> (2017) </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28256591"><span style="font-size:15px;">Nicotinic acid inhibits glioma invasion by facilitating Snail1 degradation.</span></a><span style="font-size:15px;"> </span><em style="text-decoration:underline;font-size:15px;">Sci. Rep.</em><span style="font-size:15px;"> 7, 43173.</span><br style="font-size:15px;"></p></li><li><p><span style="font-size:15px;">Fu, L., Zhang, M., Mastrantoni, K., Perfetto, M., </span><strong style="font-size:15px;">Wei, S.</strong><span style="font-size:15px;"> and Yao, J. (2016) </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27716808"><span style="font-size:15px;">Bovine Lhx8, a germ cell-specific nuclear factor, interacts with Figla.</span></a><span style="font-size:15px;"> </span><em style="text-decoration:underline;font-size:15px;">PLOS One</em><span style="font-size:15px;"> 11, e0164671.</span><br style="font-size:15px;"></p></li><li><p><span style="font-size:15px;">Bahudhanapati, H., Bhattacharya, S., and </span><strong style="font-size:15px;">Wei, S.</strong><span style="font-size:15px;"> (2015) </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26308360"><span style="font-size:15px;">Evolution of vertebrate Adam genes; duplication of testicular Adams from ancient Adam9/9-like loci.</span></a><span style="font-size:15px;"> </span><em style="text-decoration:underline;font-size:15px;">PLOS One</em><span style="font-size:15px;"> 10, e0136281.</span><br style="font-size:15px;"></p></li><li><p><span style="font-size:15px;">Christian, L., Bahudhanapati, H., and </span><strong style="font-size:15px;">Wei, S.</strong><span style="font-size:15px;"> (2013) </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24066766/"><span style="font-size:15px;">Extracellular metalloproteinases in neural crest development and craniofacial morphogenesis.</span></a><span style="font-size:15px;"> </span><em style="text-decoration:underline;font-size:15px;">Crit. Rev. Biochem. Mol. Biol.</em><span style="font-size:15px;"> 48, 544-560. Review.</span><br style="font-size:15px;"></p></li><li><p><strong style="font-size:15px;">Wei, S.</strong><span style="font-size:15px;"> (2013) </span><a href="https://www.sciencedirect.com/science/article/pii/B9780123822192002489"><span style="font-size:15px;">ADAM metalloproteinases.</span></a><span style="font-size:15px;"> In </span><em style="text-decoration:underline;font-size:15px;">The Handbook of Proteolytic Enzymes</em><span style="font-size:15px;">, 3rd edition. Edited by: Rawlings, N.D. and Salvesen, G. Oxford: Academic Press, 1086-1094. Book chapter.</span><br style="font-size:15px;"></p></li><li><p><span style="font-size:15px;">Xu, G., </span><strong style="font-size:15px;">Wei, S.</strong><span style="font-size:15px;">*, White, J.M., and DeSimone, D.W.* (2012) </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22811267"><span style="font-size:15px;">Identification and characterization of ADAM41, a novel metalloproteinase in </span></a><a href="https://www.ncbi.nlm.nih.gov/pubmed/22811267"><span style="font-size:15px;">Xenopus.</span></a><span style="font-size:15px;"> </span><em style="text-decoration:underline;font-size:15px;">Int. J. Dev. Biol.</em><span style="font-size:15px;"> 56, 333-339. * Co-senior authors.</span><br style="font-size:15px;"></p></li><li><p><strong style="font-size:15px;">Wei, S.</strong><span style="font-size:15px;">, Xu, G., Bridges, L.C., Williams, P., Nakayama, T., Shah, A., Grainger, R.M., White, J.M., and DeSimone, D.W. (2012) </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22227340"><span style="font-size:15px;">Roles of ADAM13-regulated Wnt activity in early Xenopus eye development.</span></a><span style="font-size:15px;"> </span><em style="text-decoration:underline;font-size:15px;">Dev. Biol.</em><span style="font-size:15px;"> 363, 147-154.</span><br style="font-size:15px;"></p></li><li><p><span style="font-size:15px;">Wu, Y., </span><strong style="font-size:15px;">Wei, S.</strong><span style="font-size:15px;">, Van Doren, S.R., and Brew, K. (2011) </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21454617"><span style="font-size:15px;">Entropy increases from different sources support the high-affinity binding of the N-terminal inhibitory domains of tissue inhibitors of metalloproteinases (N-TIMPs) to the catalytic domains of matrix metalloproteinases (MMPs) -1 and-3.</span></a><span style="font-size:15px;"> </span><em style="text-decoration:underline;font-size:15px;">J. Biol. Chem.</em><span style="font-size:15px;"> 286, 16891-16899.</span><br style="font-size:15px;"></p></li><li><p><strong style="font-size:15px;">Wei, S.</strong><span style="font-size:15px;">*, Xu, G., Bridges, L.C., Williams, P., White, J.M., and DeSimone, D.W.* (2010) </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20708595"><span style="font-size:15px;">ADAM13 induces cranial neural crest by cleaving class B ephrins and regulating Wnt signaling.</span></a><span style="font-size:15px;"> </span><em style="text-decoration:underline;font-size:15px;">Dev. Cell</em><span style="font-size:15px;"> 19: 345-352. * Co-senior authors.</span><br style="font-size:15px;"></p></li><li><p><strong style="font-size:15px;">Wei, S.</strong><span style="font-size:15px;">, Whittaker, C., Xu, G., Bridges, L.C., Shah, A., White, J.M., and DeSimone, D.W. (2010) </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20630080"><span style="font-size:15px;">Conservation and divergence of ADAM family proteins in the Xenopus genome.</span></a><span style="font-size:15px;"> </span><em style="text-decoration:underline;font-size:15px;">BMC Evol. Biol.</em><span style="font-size:15px;"> 10: 211.</span><br style="font-size:15px;"></p></li><li><p><span style="font-size:15px;">Van Doren, S.R., </span><strong style="font-size:15px;">Wei, S.</strong><span style="font-size:15px;">, Gao, G., Dague, B.B., Palmier, M.O., Bahudhanapati, H., and Brew, K. (2008) </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18615493"><span style="font-size:15px;">Inactivation of N-TIMP-1 by N-terminal acetylation when expressed in Bacteria.</span></a><span style="font-size:15px;"> </span><em style="text-decoration:underline;font-size:15px;">Biopolymers</em><span style="font-size:15px;"> 89: 960-968.</span><br style="font-size:15px;"></p></li><li><p><span style="font-size:15px;">Hamze A.B.†, </span><strong style="font-size:15px;">Wei, S.</strong><span style="font-size:15px;">†, Bahudhanapati, H., Kota, S., Acharya, K.R., and Brew, K. (2007) </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17660250"><span style="font-size:15px;">Constraining specificity in the N-domain of tissue inhibitor of metalloproteinases-1; gelatinase-selective inhibitors.</span></a><span style="font-size:15px;"> </span><em style="text-decoration:underline;font-size:15px;">Protein Sci.</em><span style="font-size:15px;"> 16: 1905-1913. † Equal contributors.</span><br style="font-size:15px;"></p></li><li><p><span style="font-size:15px;">Lauer-Fields, J.L., Cudic, M., </span><strong style="font-size:15px;">Wei, S.</strong><span style="font-size:15px;">, Mari, F., Fields, G.B., and Brew, K. (2007) </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17626018"><span style="font-size:15px;">Engineered sarafotoxins as TIMP-like MMP inhibitors.</span></a><span style="font-size:15px;"> </span><em style="text-decoration:underline;font-size:15px;">J. Biol. Chem.</em><span style="font-size:15px;"> 282: 26948-26955.</span><br style="font-size:15px;"></p></li><li><p><span style="font-size:15px;">Iyer, S., </span><strong style="font-size:15px;">Wei, S.</strong><span style="font-size:15px;">, Brew, K., and Acharya, K.R. (2007) </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17050530"><span style="font-size:15px;">Crystal structure of the catalytic domain of matrix metalloproteinase-1 in complex with the inhibitory domain of tissue inhibitor of metalloproteinase-1.</span></a><span style="font-size:15px;"> </span><em style="text-decoration:underline;font-size:15px;">J. Biol. Chem.</em><span style="font-size:15px;"> 282: 364-371.</span><br style="font-size:15px;"></p></li><li><p><strong style="font-size:15px;">Wei, S.</strong><span style="font-size:15px;">, Kashiwagi, M., Kota, S., Xie, Z., Nagase, H., and Brew, K. (2005) </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16079149"><span style="font-size:15px;">Reactive site mutations in TIMP-3 disrupt inhibition of MMPs but not ADAM-17 (TACE).</span></a><span style="font-size:15px;"> </span><em style="text-decoration:underline;font-size:15px;">J. Biol. Chem.</em><span style="font-size:15px;"> 280: 32877-32882.</span><br style="font-size:15px;"></p></li><li><p><span style="font-size:15px;">Cui, T., </span><strong style="font-size:15px;">Wei, S.</strong><span style="font-size:15px;">, Brew, K., and Leng, F. (2005) </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16109425"><span style="font-size:15px;">Energetics of binding the mammalian high mobility group protein HMGA2 to poly(dA-dT)2 and poly(dA)poly(dT).</span></a><span style="font-size:15px;"> </span><em style="text-decoration:underline;font-size:15px;">J. Mol. Biol.</em><span style="font-size:15px;"> 352: 629-645.</span><br style="font-size:15px;"></p></li><li><p><strong style="font-size:15px;">Wei, S.</strong><span style="font-size:15px;">, Xie, Z., Filenova, E., and Brew, K. (2003) </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/14567681"><span style="font-size:15px;">Drosophila</span></a><span style="font-size:15px;"> </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/14567681"><span style="font-size:15px;">TIMP is a potent inhibitor of MMPs and TACE: similarities in structure and function to TIMP-3.</span></a><span style="font-size:15px;"> </span><em style="text-decoration:underline;font-size:15px;">Biochemistry</em><span style="font-size:15px;"> 42: 12200-12207.</span><br style="font-size:15px;"></p></li><li><p><strong style="font-size:15px;">Wei, S.</strong><span style="font-size:15px;">, Chen, Y., Chung, L., Nagase, H., and Brew, K. (2003) </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12515831"><span style="font-size:15px;">Protein engineering of the tissue inhibitor of metalloproteinase 1 (TIMP-1) inhibitory domain. In search of selective matrix metalloproteinase inhibitors.</span></a><span style="font-size:15px;"> </span><em style="text-decoration:underline;font-size:15px;">J. Biol. Chem.</em><span style="font-size:15px;"> 278: 9831-9834.</span><br></p></li></span></ul><p></p><img alt="Dr. Shuo Wei" src="/content-sub-site/PublishingImages/people/swei/swei.jpg" style="BORDER:0px solid;" />

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Open the image pane in this body section. Click in the image pane to select an image from the image library.

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Open the video pane in this body section. Click in the video pane to embed a video. Click ? for step-by-step instructions.

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Remove the image from the media panel. This does not delete the image from the library.

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Open the image pane in this body section. Click in the image pane to select an image from the image library.

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Open the video pane in this body section. Click in the video pane to embed a video. Click ? for step-by-step instructions.

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Remove the image from the media panel. This does not delete the image from the library.

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Remove the video from the media panel.

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Insert Image

Open the image pane in this body section. Click in the image pane to select an image from the image library.

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Open the video pane in this body section. Click in the video pane to embed a video. Click ? for step-by-step instructions.

Remove Image

Remove the image from the media panel. This does not delete the image from the library.

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Remove the video from the media panel.

Move Up

Move this whole section up, swapping places with the section above it.

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Align the media panel to the right/left in this section.

Insert Image

Open the image pane in this body section. Click in the image pane to select an image from the image library.

Insert Video

Open the video pane in this body section. Click in the video pane to embed a video. Click ? for step-by-step instructions.

Remove Image

Remove the image from the media panel. This does not delete the image from the library.

Remove Video

Remove the video from the media panel.

Move Up

Move this whole section up, swapping places with the section above it.

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Move this whole section down, swapping places with the section below it.

Code Cleaner

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Original
50%
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Align the media panel to the right/left in this section.

Insert Image

Open the image pane in this body section. Click in the image pane to select an image from the image library.

Insert Video

Open the video pane in this body section. Click in the video pane to embed a video. Click ? for step-by-step instructions.

Remove Image

Remove the image from the media panel. This does not delete the image from the library.

Remove Video

Remove the video from the media panel.

Move Up

Move this whole section up, swapping places with the section above it.

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Move this whole section down, swapping places with the section below it.

Code Cleaner

Check for and fix problems in the body text. Text pasted in from other sources may contain malformed HTML which the code cleaner will remove.

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Align the media panel to the right/left in this section.

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Code Cleaner

Check for and fix problems in the body text. Text pasted in from other sources may contain malformed HTML which the code cleaner will remove.

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Media Right/Left-Align

Align the media panel to the right/left in this section.

Move Up

Move this whole section up, swapping places with the section above it.

Move Down

Move this whole section down, swapping places with the section below it.

Code Cleaner

Check for and fix problems in the body text. Text pasted in from other sources may contain malformed HTML which the code cleaner will remove.

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Media Right/Left-Align

Align the media panel to the right/left in this section.

Move Up

Move this whole section up, swapping places with the section above it.

Code Cleaner

Check for and fix problems in the body text. Text pasted in from other sources may contain malformed HTML which the code cleaner will remove.

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