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305Andre Luiz Pasqua Tavares, DDS, PhD<p>​​​​​​​Assistant Professor<br></p>tavaresa@udel.edu322 Wolf Hall262 Wolf Hall<p>​D.D.S. – Federal Univers​​ity of Alfenas</p><p>MS. – Federal Universi​​ty of Minas Gerais</p><p>Ph.D. – Federal Universit​​​y of Minas Gerais</p><p>Postdoctoral – University of Arizona and University of Colorado Anschutz Medical Campus​​​​<br><br></p><ul><li><p>Our ​​goal is to determine the role of the transcription factor SIX1 and SIX1-associated genes in de​velopment of the cranial bones, jaws and ear using transgenic mice and Xenopus (frog).</p></li><li><p>Our overarching goal is to help patients and their families understand the gen​etic causes of SIX1-related birth defects (e.g., branchio-oto-renal syndrome, craniosynostosis), and to develop preventive and corrective strategies.​</p><p><br></p></li></ul><p></p><ol><li><span style="font-size:13px;"><span style="text-decoration:underline;">​​​Six1 role du​​​ring s​​​kull bone and suture development and disease</span>: Analyzing the role of Six1 and Six1-ass​​​ociated gen​es in development of the mouse cranial bones and sutures; Determining the link between Six1 and the pathogenesis of premature suture closure (craniosynostosis)</span></li><li><u>Six1 co-factors function during development of the jaws and ear</u>: Uncovering the function of ​Six1-associated genes (co-factors) during development of the craniofacial cartilages and inner ear in Xenopus (frog); Dissecting the role of Six1 co-factors during development of the jaws and middle ear in mouse.</li><li><u>S​​ix1 and co-factors role during tooth development:</u> Determining the function of Six1​ and Six1 co-factors during incisor development in mouse.​</li></ol><p></p><p><br></p><br><p>​<span class="s1" style="text-decoration-line:underline;"><a href="https://tavareslab.bio.udel.edu/">https://tavareslab.bio.udel.edu/</a></span><br></p><p><br></p><ol><li><span style="font-size:13px;">​​​​Baxi, A., Jourdeuil, K., Cox, T.C., Clouthier, D.E., <b>TAVARES, A.L.</b> (corresponding author). 2​023. Transcriptomic analysis reveals the role of SIX1 in mouse cranial neural ​​crest patterning an​d bone development. <i>Developmental Dynamics</i>. PMID: 37183792</span></li><li>Keer, S., Cousin, H., Jourdeuil, K., Neilson, K.M., <b>TAVARES, A.L.</b>, Alfandari, D., Moody, S.A. 2022. Mcrs1 is required for branchia​l arch and cranial cartilage development. <i>Developmental Biology</i>. PMID: 35697116.</li><li>Klein S.L.; <b>TAVARES, A.L.</b> (equal contribution), Sullivan, C.H., Moody S.A. 2022. Repressive interactions between transcription factors separate different embryonic ectoder​​mal domains. <i>Frontiers in Cell and Developmental Biology</i>. PMID: 35198557.</li><li>Coppenrath​, K., <b>TAVARES, A.L.</b> (equal contribution), Shaidani, N., Wlizla, M., Moody, S.A., Horb, M. 2021. Generation of a new six1-null line in Xenopus tropicalis for study​ of development and congenital disease. <i>Genesis</i>. PMID: 34664392</li><li><b>TAVARES, A.L.</b> (corresponding author), Jourdeuil, K., Neilson, K.M., Majumdar, H.D., Moody, S.A. 2021. Sobp​ modulates Six1 transcriptional activation and is required during craniofacial development. <i>Development</i>. PMID: 34414417</li><li>Mehdizadeh, T. Majumdar, H.D., Ahsan, S., <b>TAVARES, A.L.</b>, Moody, S.A. 2021. Mutation in SIX1 associated with Branchio-oto-renal Syndrome (BOR) differentially affect otic expression of putative target genes. Journal of <i>Developmental Biology</i>. PMID: 3420​8995</li><li>Shah, A.M.; Krohn, P.; Baxi, A.B.; <strong>TAVARES, A.L.</strong>; Sulllivan, C.H.; Chillakuru, Y.R.; Majumdar, H.D.; Neilson, K.M.; Moody, S.A. 2020. Six1 proteins with human Branchio-Oto-Renal mutations differentially affect cranial gene expression and otic development. <em>Disease, Models & Mechanisms</em>. PMID: 31980437</li><li>Pritchard, A.B.; Kanai, S.M.; Krock, B.; Schindwolf, E.; Oliver-Krasinski, J.; Kahlek, N.; Okashah, N.; Lambert, N.A.; <b>TAVARES, A.L.</b>; Zackai, E.; Clouthier, D.E. 2020. Loss-of-Function of Endothelin Receptor Type A results in Oro-Oto-Cardiac Syndro​me. <i>The American Journal of Medical Genetics</i>. PMID: 32133772</li><li><b>TAVARES, A.L.</b>; Brown, J.A.; Ulrich, E.C.; Dvorak, K.; Runyan, R.B. 2018. Runx2-I is an early regulator of epithelial-mesenchymal cell transition in the chick embr​yo. <em>Developmental Dynamics</em>, v.247, n.3, p.542 – 554. PMID: 28631378</li><li><b>TAVARES, A.L.</b>; Cox, T.C.; Maxson, R.M.; Ford, H.; Clouthier, D.E. 2017. Negative re​​gulation of endothelin signaling by SIX1 is required for proper maxillary development. <i>Development</i>, v.144, n.11, p.2021 – 2031. PMID: 28455376</li><li>Gordon, C.T.; Weave K.N., Zechi-Ceide, R.M., Madsen, E.C., <strong>TAVARES, A.L.</strong> (equal contribution) et al. 2015. Mutations in the endothelin receptor type A cause mandibulofacial dysostosis with alopecia. <em>The American Journal of Human Genetics</em>, v.96, n.4, p.519 – 531. PMID: 25​​​772936</li><li><strong>TAVARES, A.L.</strong>; Clo​uthier, D.E. 2015. Cre recombinase-regulated Endothelin1 transgenic mouse lines: novel tools for analysis of embryonic and adult disorders.  <em>Developmental Biology</em>, v.400, n.2, p.191 – 201. PMID: 25725491</li><li>Clout​​hier, D.E., Passos-Bueno, M.R., <strong>TAVARES, A.L.</strong>, Lyonnet, S., Amiel, J., Gordon, C.T. 2013. <a href="http://www.ncbi.nlm.nih.gov/pubmed/24123988">Understanding the basis of auriculocondylar syndrome: Insights from human, mouse and zebrafish genetic studies.</a> <em>Am J Med Genet C Semin Med Genet</em>., v.163C, n.4, p.306 – 317. PMID: 24123988</li><li><strong style="font-family:arial;">​TAVAR​​​​ES, A.L.</strong><span style="font-family:arial;">, Garcia, E.L., Kuhn, K., Woods, C.M., Williams, T., Clouthier, D.E. 2012. </span><a href="http://www.ncbi.nlm.nih.gov/pubmed/22902530" style="font-family:arial;">Ectodermal-derived Endothelin1 is required for patterning the distal and intermediate domains of the mouse mandibular arch.</a><span style="font-family:arial;"> </span><em style="font-family:arial;">Developmental Biology</em><span style="font-family:arial;">, v.371, n.1, p.47 – 56. PMID: 22902530</span></li></ol><p></p><br><img alt="" src="/Images%20Bios/Tavares-Andre.jpeg" style="BORDER:0px solid;" />

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